Palmitoyl-protein thioesterase 1 (PPT1)

About Palmitoyl-protein thioesterase 1

Palmitoyl-protein thioesterase 1 (PPT1) is a protein from Homo sapiens identified by UniProt accession P50897, 306 residues long. MolForge cross-references it against 0 known binders and 200 disease associations.

Target properties

Protein name	Palmitoyl-protein thioesterase 1
UniProt accession	P50897
Gene	PPT1
Organism	Homo sapiens
Length	306 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (200)

Diseases linked to this target (Open Targets).

neuronal ceroid lipofuscinosis 1 · score 0.85
CLN1 disease · score 0.73
neuronal ceroid lipofuscinosis · score 0.64
genetic disorder · score 0.53
neurodegenerative disease · score 0.46
lysosomal storage disease · score 0.46
Parkinson disease · score 0.46
Alzheimer disease · score 0.46
multiple sclerosis · score 0.46
retinitis pigmentosa · score 0.43

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-P50897-F1	alphafold	PREDICTED	91.68	—

Amino-acid sequence (306 residues)

MASPGCLWLL AVALLPWTCA SRALQHLDPP APLPLVIWHG MGDSCCNPLS MGAIKKMVEK KIPGIYVLSL EIGKTLMEDV ENSFFLNVNS QVTTVCQALA KDPKLQQGYN AMGFSQGGQF LRAVAQRCPS PPMINLISVG GQHQGVFGLP RCPGESSHIC DFIRKTLNAG AYSKVVQERL VQAEYWHDPI KEDVYRNHSI FLADINQERG INESYKKNLM ALKKFVMVKF LNDSIVDPVD SEWFGFYRSG QAKETIPLQE TSLYTQDRLG LKEMDNAGQL VFLATEGDHL QLSEEWFYAH IIPFLG

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards