About Large ribosomal subunit protein eL14
Large ribosomal subunit protein eL14 (RPL14) is a protein
from Homo sapiens identified by UniProt accession
P50914, 215 residues long.
MolForge cross-references it against 0 known binders and
66 disease associations.
Target properties
| Protein name | Large ribosomal subunit protein eL14 |
|---|
| UniProt accession | P50914 |
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| Gene | RPL14 |
|---|
| Organism | Homo sapiens |
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| Length | 215 residues |
|---|
| Molecular weight | — |
|---|
| EC numbers | — |
|---|
| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
|---|
Disease associations (66)
Diseases linked to this target (Open Targets).
- Duchenne muscular dystrophy · score 0.50
- cystic fibrosis · score 0.50
- influenza · score 0.46
- neurodegenerative disease · score 0.41
- Becker muscular dystrophy · score 0.29
- qualitative or quantitative defects of dystrophin · score 0.26
- renal cell carcinoma · score 0.14
- colorectal cancer · score 0.09
- aniridia · score 0.09
- eosinophil percentage of leukocytes · score 0.09
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-P50914-F1 | alphafold | PREDICTED | 76.56 | — |
Amino-acid sequence (215 residues)
MVFRRFVEVG RVAYVSFGPH AGKLVAIVDV IDQNRALVDG PCTQVRRQAM PFKCMQLTDF ILKFPHSAHQ KYVRQAWQKA DINTKWAATR WAKKIEARER KAKMTDFDRF KVMKAKKMRN RIIKNEVKKL QKAALLKASP KKAPGTKGTA AAAAAAAAAK VPAKKITAAS KKAPAQKVPA QKATGQKAAP APKAQKGQKA PAQKAPAPKA SGKKA
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