About T-complex protein 1 subunit theta
T-complex protein 1 subunit theta (CCT8) is a protein
from Homo sapiens identified by UniProt accession
P50990, 548 residues long.
MolForge cross-references it against 0 known binders and
90 disease associations.
Target properties
| Protein name | T-complex protein 1 subunit theta |
|---|
| UniProt accession | P50990 |
|---|
| Gene | CCT8 |
|---|
| Organism | Homo sapiens |
|---|
| Length | 548 residues |
|---|
| Molecular weight | — |
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| EC numbers | — |
|---|
| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
|---|
Disease associations (90)
Diseases linked to this target (Open Targets).
- head and neck squamous cell carcinoma · score 0.25
- gastric adenocarcinoma · score 0.25
- breast adenocarcinoma · score 0.25
- serum gamma-glutamyl transferase measurement · score 0.15
- serum alanine aminotransferase measurement · score 0.12
- electrocardiography · score 0.09
- reticulocyte count · score 0.08
- cancer · score 0.08
- hepatocellular carcinoma · score 0.08
- colorectal carcinoma · score 0.07
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-P50990-F1 | alphafold | PREDICTED | 87.72 | — |
Amino-acid sequence (548 residues)
MALHVPKAPG FAQMLKEGAK HFSGLEEAVY RNIQACKELA QTTRTAYGPN GMNKMVINHL EKLFVTNDAA TILRELEVQH PAAKMIVMAS HMQEQEVGDG TNFVLVFAGA LLELAEELLR IGLSVSEVIE GYEIACRKAH EILPNLVCCS AKNLRDIDEV SSLLRTSIMS KQYGNEVFLA KLIAQACVSI FPDSGHFNVD NIRVCKILGS GISSSSVLHG MVFKKETEGD VTSVKDAKIA VYSCPFDGMI TETKGTVLIK TAEELMNFSK GEENLMDAQV KAIADTGANV VVTGGKVADM ALHYANKYNI MLVRLNSKWD LRRLCKTVGA TALPRLTPPV LEEMGHCDSV YLSEVGDTQV VVFKHEKEDG AISTIVLRGS TDNLMDDIER AVDDGVNTFK VLTRDKRLVP GGGATEIELA KQITSYGETC PGLEQYAIKK FAEAFEAIPR ALAENSGVKA NEVISKLYAV HQEGNKNVGL DIEAEVPAVK DMLEAGILDT YLGKYWAIKL ATNAAVTVLR VDQIIMAKPA GGPKPPSGKK DWDDDQND
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