About T-complex protein 1 subunit delta
T-complex protein 1 subunit delta (CCT4) is a protein
from Homo sapiens identified by UniProt accession
P50991, 539 residues long.
MolForge cross-references it against 0 known binders and
94 disease associations.
Target properties
| Protein name | T-complex protein 1 subunit delta |
|---|
| UniProt accession | P50991 |
|---|
| Gene | CCT4 |
|---|
| Organism | Homo sapiens |
|---|
| Length | 539 residues |
|---|
| Molecular weight | — |
|---|
| EC numbers | — |
|---|
| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
|---|
Disease associations (94)
Diseases linked to this target (Open Targets).
- ovarian cancer · score 0.27
- head and neck squamous cell carcinoma · score 0.25
- lung adenocarcinoma · score 0.25
- gastric adenocarcinoma · score 0.25
- breast adenocarcinoma · score 0.25
- neurodegenerative disease · score 0.17
- amino acid measurement · score 0.13
- 17-hydroxyprogesterone measurement · score 0.12
- methionine measurement · score 0.11
- threonine measurement · score 0.10
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-P50991-F1 | alphafold | PREDICTED | 89.68 | — |
Amino-acid sequence (539 residues)
MPENVAPRSG ATAGAAGGRG KGAYQDRDKP AQIRFSNISA AKAVADAIRT SLGPKGMDKM IQDGKGDVTI TNDGATILKQ MQVLHPAARM LVELSKAQDI EAGDGTTSVV IIAGSLLDSC TKLLQKGIHP TIISESFQKA LEKGIEILTD MSRPVELSDR ETLLNSATTS LNSKVVSQYS SLLSPMSVNA VMKVIDPATA TSVDLRDIKI VKKLGGTIDD CELVEGLVLT QKVSNSGITR VEKAKIGLIQ FCLSAPKTDM DNQIVVSDYA QMDRVLREER AYILNLVKQI KKTGCNVLLI QKSILRDALS DLALHFLNKM KIMVIKDIER EDIEFICKTI GTKPVAHIDQ FTADMLGSAE LAEEVNLNGS GKLLKITGCA SPGKTVTIVV RGSNKLVIEE AERSIHDALC VIRCLVKKRA LIAGGGAPEI ELALRLTEYS RTLSGMESYC VRAFADAMEV IPSTLAENAG LNPISTVTEL RNRHAQGEKT AGINVRKGGI SNILEELVVQ PLLVSVSALT LATETVRSIL KIDDVVNTR
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