Annexin A11 (ANXA11)

About Annexin A11

Annexin A11 (ANXA11) is a protein from Homo sapiens identified by UniProt accession P50995, 505 residues long. MolForge cross-references it against 0 known binders and 86 disease associations.

Target properties

Protein name	Annexin A11
UniProt accession	P50995
Gene	ANXA11
Organism	Homo sapiens
Length	505 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (86)

Diseases linked to this target (Open Targets).

amyotrophic lateral sclerosis · score 0.65
inclusion body myopathy and brain white matter abnormalities · score 0.46
sarcoidosis · score 0.39
Amyotrophic lateral sclerosis · score 0.38
oculopharyngeal muscular dystrophy · score 0.34
immune system disease · score 0.27
genetic disorder · score 0.19
serum urea measurement · score 0.14
axial length measurement · score 0.10
drug use measurement · score 0.08

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-P50995-F1	alphafold	PREDICTED	75.79	—

Amino-acid sequence (505 residues)

MSYPGYPPPP GGYPPAAPGG GPWGGAAYPP PPSMPPIGLD NVATYAGQFN QDYLSGMAAN MSGTFGGANM PNLYPGAPGA GYPPVPPGGF GQPPSAQQPV PPYGMYPPPG GNPPSRMPSY PPYPGAPVPG QPMPPPGQQP PGAYPGQPPV TYPGQPPVPL PGQQQPVPSY PGYPGSGTVT PAVPPTQFGS RGTITDAPGF DPLRDAEVLR KAMKGFGTDE QAIIDCLGSR SNKQRQQILL SFKTAYGKDL IKDLKSELSG NFEKTILALM KTPVLFDIYE IKEAIKGVGT DEACLIEILA SRSNEHIREL NRAYKAEFKK TLEEAIRSDT SGHFQRLLIS LSQGNRDEST NVDMSLAQRD AQELYAAGEN RLGTDESKFN AVLCSRSRAH LVAVFNEYQR MTGRDIEKSI CREMSGDLEE GMLAVVKCLK NTPAFFAERL NKAMRGAGTK DRTLIRIMVS RSETDLLDIR SEYKRMYGKS LYHDISGDTS GDYRKILLKI CGGND

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards