About RNA-binding protein FXR1
RNA-binding protein FXR1 (FXR1) is a protein
from Homo sapiens identified by UniProt accession
P51114, 621 residues long.
MolForge cross-references it against 0 known binders and
134 disease associations.
Target properties
| Protein name | RNA-binding protein FXR1 |
|---|
| UniProt accession | P51114 |
|---|
| Gene | FXR1 |
|---|
| Organism | Homo sapiens |
|---|
| Length | 621 residues |
|---|
| Molecular weight | — |
|---|
| EC numbers | — |
|---|
| Target class | UNCLASSIFIED |
|---|
| Subcellular location | — |
|---|
| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
|---|
Disease associations (134)
Diseases linked to this target (Open Targets).
- myopathy, congenital proximal, with minicore lesions · score 0.59
- cancer · score 0.57
- myopathy, congenital, with respiratory insufficiency and bone fractures · score 0.50
- congenital myopathy · score 0.41
- schizophrenia · score 0.35
- thyroid gland adenocarcinoma · score 0.26
- Intellectual disability · score 0.26
- anorexia nervosa · score 0.25
- lung adenocarcinoma · score 0.24
- multiple myeloma · score 0.22
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-P51114-F1 | alphafold | PREDICTED | 70.18 | — |
Amino-acid sequence (621 residues)
MAELTVEVRG SNGAFYKGFI KDVHEDSLTV VFENNWQPER QVPFNEVRLP PPPDIKKEIS EGDEVEVYSR ANDQEPCGWW LAKVRMMKGE FYVIEYAACD ATYNEIVTFE RLRPVNQNKT VKKNTFFKCT VDVPEDLREA CANENAHKDF KKAVGACRIF YHPETTQLMI LSASEATVKR VNILSDMHLR SIRTKLMLMS RNEEATKHLE CTKQLAAAFH EEFVVREDLM GLAIGTHGSN IQQARKVPGV TAIELDEDTG TFRIYGESAD AVKKARGFLE FVEDFIQVPR NLVGKVIGKN GKVIQEIVDK SGVVRVRIEG DNENKLPRED GMVPFVFVGT KESIGNVQVL LEYHIAYLKE VEQLRMERLQ IDEQLRQIGS RSYSGRGRGR RGPNYTSGYG TNSELSNPSE TESERKDELS DWSLAGEDDR DSRHQRDSRR RPGGRGRSVS GGRGRGGPRG GKSSISSVLK DPDSNPYSLL DNTESDQTAD TDASESHHST NRRRRSRRRR TDEDAVLMDG MTESDTASVN ENGLVTVADY ISRAESQSRQ RNLPRETLAK NKKEMAKDVI EEHGPSEKAI NGPTSASGDD ISKLQRTPGE EKINTLKEEN TQEAAVLNGV S
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