About RNA-binding protein FXR2
RNA-binding protein FXR2 (FXR2) is a protein
from Homo sapiens identified by UniProt accession
P51116, 673 residues long.
MolForge cross-references it against 0 known binders and
72 disease associations.
Target properties
| Protein name | RNA-binding protein FXR2 |
|---|
| UniProt accession | P51116 |
|---|
| Gene | FXR2 |
|---|
| Organism | Homo sapiens |
|---|
| Length | 673 residues |
|---|
| Molecular weight | — |
|---|
| EC numbers | — |
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| Target class | UNCLASSIFIED |
|---|
| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
|---|
Disease associations (72)
Diseases linked to this target (Open Targets).
- sex hormone-binding globulin measurement · score 0.54
- neurodegenerative disease · score 0.37
- testosterone measurement · score 0.21
- Red cell distribution width · score 0.18
- monocyte count · score 0.17
- Calcium channel blocker use measurement · score 0.13
- body height · score 0.11
- PHF-tau measurement · score 0.08
- apolipoprotein A 1 measurement · score 0.08
- eosinophil percentage of leukocytes · score 0.08
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-P51116-F1 | alphafold | PREDICTED | 68.20 | — |
Amino-acid sequence (673 residues)
MGGLASGGDV EPGLPVEVRG SNGAFYKGFV KDVHEDSVTI FFENNWQSER QIPFGDVRLP PPADYNKEIT EGDEVEVYSR ANEQEPCGWW LARVRMMKGD FYVIEYAACD ATYNEIVTLE RLRPVNPNPL ATKGSFFKVT MAVPEDLREA CSNENVHKEF KKALGANCIF LNITNSELFI LSTTEAPVKR ASLLGDMHFR SLRTKLLLMS RNEEATKHLE TSKQLAAAFQ EEFTVREDLM GLAIGTHGAN IQQARKVPGV TAIELGEETC TFRIYGETPE ACRQARSYLE FSEDSVQVPR NLVGKVIGKN GKVIQEIVDK SGVVRVRVEG DNDKKNPREE GMVPFIFVGT RENISNAQAL LEYHLSYLQE VEQLRLERLQ IDEQLRQIGL GFRPPGSGRG SGGSDKAGYS TDESSSSSLH ATRTYGGSYG GRGRGRRTGG PAYGPSSDVS TASETESEKR EEPNRAGPGD RDPPTRGEES RRRPTGGRGR GPPPAPRPTS RYNSSSISSV LKDPDSNPYS LLDTSEPEPP VDSEPGEPPP ASARRRRSRR RRTDEDRTVM DGGLESDGPN MTENGLEDES RPQRRNRSRR RRNRGNRTDG SISGDRQPVT VADYISRAES QSRQRPPLER TKPSEDSLSG QKGDSVSKLP KGPSENGELS APLELGSMVN GVS
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