About Granzyme M
Granzyme M (GZMM) is a protein
from Homo sapiens identified by UniProt accession
P51124, 257 residues long.
MolForge cross-references it against 0 known binders and
69 disease associations.
Target properties
| Protein name | Granzyme M |
|---|
| UniProt accession | P51124 |
|---|
| Gene | GZMM |
|---|
| Organism | Homo sapiens |
|---|
| Length | 257 residues |
|---|
| Molecular weight | — |
|---|
| EC numbers | — |
|---|
| Target class | UNCLASSIFIED |
|---|
| Subcellular location | — |
|---|
| Keywords | — |
|---|
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
|---|
Disease associations (69)
Diseases linked to this target (Open Targets).
- cutaneous melanoma · score 0.10
- neoplasm · score 0.09
- blood protein measurement · score 0.07
- varicella, severe recurrent · score 0.07
- immunodeficiency 28 · score 0.05
- immunodeficiency 31B · score 0.05
- insomnia · score 0.04
- total blood protein measurement · score 0.04
- cancer · score 0.03
- carcinoma · score 0.02
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-P51124-F1 | alphafold | PREDICTED | 90.26 | — |
Amino-acid sequence (257 residues)
MEACVSSLLV LALGALSVGS SFGTQIIGGR EVIPHSRPYM ASLQRNGSHL CGGVLVHPKW VLTAAHCLAQ RMAQLRLVLG LHTLDSPGLT FHIKAAIQHP RYKPVPALEN DLALLQLDGK VKPSRTIRPL ALPSKRQVVA AGTRCSMAGW GLTHQGGRLS RVLRELDLQV LDTRMCNNSR FWNGSLSPSM VCLAADSKDQ APCKGDSGGP LVCGKGRVLA RVLSFSSRVC TDIFKPPVAT AVAPYVSWIR KVTGRSA
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