About Cone cGMP-specific 3',5'-cyclic phosphodiesterase subunit alpha'
Cone cGMP-specific 3',5'-cyclic phosphodiesterase subunit alpha' (PDE6C) is a protein
from Homo sapiens identified by UniProt accession
P51160, 858 residues long.
MolForge cross-references it against 0 known binders and
147 disease associations.
Target properties
| Protein name | Cone cGMP-specific 3',5'-cyclic phosphodiesterase subunit alpha' |
|---|
| UniProt accession | P51160 |
|---|
| Gene | PDE6C |
|---|
| Organism | Homo sapiens |
|---|
| Length | 858 residues |
|---|
| Molecular weight | — |
|---|
| EC numbers | — |
|---|
| Target class | UNCLASSIFIED |
|---|
| Subcellular location | — |
|---|
| Keywords | — |
|---|
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
|---|
Approved drugs hitting this target (2)
DrugCentral-linked approved drugs that act on this protein.
Disease associations (147)
Diseases linked to this target (Open Targets).
- Cone rod dystrophy · score 0.78
- Progressive cone dystrophy · score 0.70
- achromatopsia · score 0.68
- coronary artery disease · score 0.55
- stroke · score 0.55
- Hepatitis, Alcoholic · score 0.48
- diabetic nephropathy · score 0.47
- chronic kidney disease · score 0.47
- Myocardial Ischemia · score 0.47
- diabetes mellitus · score 0.46
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-P51160-F1 | alphafold | PREDICTED | 88.26 | — |
Amino-acid sequence (858 residues)
MGEINQVAVE KYLEENPQFA KEYFDRKLRV EVLGEIFKNS QVPVQSSMSF SELTQVEESA LCLELLWTVQ EEGGTPEQGV HRALQRLAHL LQADRCSMFL CRSRNGIPEV ASRLLDVTPT SKFEDNLVGP DKEVVFPLDI GIVGWAAHTK KTHNVPDVKK NSHFSDFMDK QTGYVTKNLL ATPIVVGKEV LAVIMAVNKV NASEFSKQDE EVFSKYLNFV SIILRLHHTS YMYNIESRRS QILMWSANKV FEELTDVERQ FHKALYTVRS YLNCERYSIG LLDMTKEKEF YDEWPIKLGE VEPYKGPKTP DGREVNFYKI IDYILHGKEE IKVIPTPPAD HWTLISGLPT YVAENGFICN MMNAPADEYF TFQKGPVDET GWVIKNVLSL PIVNKKEDIV GVATFYNRKD GKPFDEHDEY ITETLTQFLG WSLLNTDTYD KMNKLENRKD IAQEMLMNQT KATPEEIKSI LKFQEKLNVD VIDDCEEKQL VAILKEDLPD PRSAELYEFR FSDFPLTEHG LIKCGIRLFF EINVVEKFKV PVEVLTRWMY TVRKGYRAVT YHNWRHGFNV GQTMFTLLMT GRLKKYYTDL EAFAMLAAAF CHDIDHRGTN NLYQMKSTSP LARLHGSSIL ERHHLEYSKT LLQDESLNIF QNLNKRQFET VIHLFEVAII ATDLALYFKK RTMFQKIVDA CEQMQTEEEA IKYVTVDPTK KEIIMAMMMT ACDLSAITKP WEVQSQVALM VANEFWEQGD LERTVLQQQP IPMMDRNKRD ELPKLQVGFI DFVCTFVYKE FSRFHKEITP MLSGLQNNRV EWKSLADEYD AKMKVIEEEA KKQEGGAEKA AEDSGGGDDK KSKTCLML
Explore Cone cGMP-specific 3',5'-cyclic phosphodiesterase subunit alpha' with MolForge
Find binders, run structure-based screening, and map this target across
diseases and approved drugs with our AI-powered platform.
Browse all targets