Potassium-transporting ATPase subunit beta (ATP4B)

About Potassium-transporting ATPase subunit beta

Potassium-transporting ATPase subunit beta (ATP4B) is a protein from Homo sapiens identified by UniProt accession P51164, 291 residues long. MolForge cross-references it against 0 known binders and 62 disease associations.

Target properties

Protein name	Potassium-transporting ATPase subunit beta
UniProt accession	P51164
Gene	ATP4B
Organism	Homo sapiens
Length	291 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (62)

Diseases linked to this target (Open Targets).

Helicobacter pylori infectious disease · score 0.60
gastroesophageal reflux disease · score 0.58
Peptic ulcer · score 0.53
duodenal ulcer · score 0.52
hemorrhage · score 0.44
peptic esophagitis · score 0.43
gastric ulcer · score 0.41
gastric cancer · score 0.37
Laryngopharyngeal Reflux · score 0.26
chronic gastritis · score 0.26

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-P51164-F1	alphafold	PREDICTED	90.59	—

Amino-acid sequence (291 residues)

MAALQEKKTC GQRMEEFQRY CWNPDTGQML GRTLSRWVWI SLYYVAFYVV MTGLFALCLY VLMQTVDPYT PDYQDQLRSP GVTLRPDVYG EKGLEIVYNV SDNRTWADLT QTLHAFLAGY SPAAQEDSIN CTSEQYFFQE SFRAPNHTKF SCKFTADMLQ NCSGLADPNF GFEEGKPCFI IKMNRIVKFL PSNGSAPRVD CAFLDQPREL GQPLQVKYYP PNGTFSLHYF PYYGKKAQPH YSNPLVAAKL LNIPRNAEVA IVCKVMAEHV TFNNPHDPYE GKVEFKLKIE K

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards