About Epithelial sodium channel subunit beta
Epithelial sodium channel subunit beta (SCNN1B) is a protein
from Homo sapiens identified by UniProt accession
P51168, 640 residues long.
MolForge cross-references it against 0 known binders and
154 disease associations.
Target properties
| Protein name | Epithelial sodium channel subunit beta |
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| UniProt accession | P51168 |
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| Gene | SCNN1B |
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| Organism | Homo sapiens |
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| Length | 640 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Disease associations (154)
Diseases linked to this target (Open Targets).
- bronchiectasis with or without elevated sweat chloride 1 · score 0.77
- Bronchiectasis · score 0.72
- Liddle syndrome · score 0.71
- autosomal recessive pseudohypoaldosteronism type 1 · score 0.68
- Generalized pseudohypoaldosteronism type 1 · score 0.65
- pseudohypoaldosteronism, type IB2, autosomal recessive · score 0.63
- bronchiectasis · score 0.47
- idiopathic bronchiectasis · score 0.37
- gut microbiome measurement · score 0.32
- nephrolithiasis · score 0.28
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-P51168-F1 | alphafold | PREDICTED | 82.47 | — |
Amino-acid sequence (640 residues)
MHVKKYLLKG LHRLQKGPGY TYKELLVWYC DNTNTHGPKR IICEGPKKKA MWFLLTLLFA ALVCWQWGIF IRTYLSWEVS VSLSVGFKTM DFPAVTICNA SPFKYSKIKH LLKDLDELME AVLERILAPE LSHANATRNL NFSIWNHTPL VLIDERNPHH PMVLDLFGDN HNGLTSSSAS EKICNAHGCK MAMRLCSLNR TQCTFRNFTS ATQALTEWYI LQATNIFAQV PQQELVEMSY PGEQMILACL FGAEPCNYRN FTSIFYPHYG NCYIFNWGMT EKALPSANPG TEFGLKLILD IGQEDYVPFL ASTAGVRLML HEQRSYPFIR DEGIYAMSGT ETSIGVLVDK LQRMGEPYSP CTVNGSEVPV QNFYSDYNTT YSIQACLRSC FQDHMIRNCN CGHYLYPLPR GEKYCNNRDF PDWAHCYSDL QMSVAQRETC IGMCKESCND TQYKMTISMA DWPSEASEDW IFHVLSQERD QSTNITLSRK GIVKLNIYFQ EFNYRTIEES AANNIVWLLS NLGGQFGFWM GGSVLCLIEF GEIIIDFVWI TIIKLVALAK SLRQRRAQAS YAGPPPTVAE LVEAHTNFGF QPDTAPRSPN TGPYPSEQAL PIPGTPPPNY DSLRLQPLDV IESDSEGDAI
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