About Epithelial sodium channel subunit gamma
Epithelial sodium channel subunit gamma (SCNN1G) is a protein
from Homo sapiens identified by UniProt accession
P51170, 649 residues long.
MolForge cross-references it against 0 known binders and
132 disease associations.
Target properties
| Protein name | Epithelial sodium channel subunit gamma |
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| UniProt accession | P51170 |
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| Gene | SCNN1G |
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| Organism | Homo sapiens |
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| Length | 649 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Disease associations (132)
Diseases linked to this target (Open Targets).
- bronchiectasis with or without elevated sweat chloride 3 · score 0.66
- Liddle syndrome · score 0.64
- autosomal recessive pseudohypoaldosteronism type 1 · score 0.64
- Generalized pseudohypoaldosteronism type 1 · score 0.64
- Liddle syndrome 2 · score 0.58
- Bronchiectasis · score 0.55
- bronchiectasis · score 0.46
- neurodegenerative disease · score 0.38
- idiopathic bronchiectasis · score 0.37
- heel bone mineral density · score 0.33
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-P51170-F1 | alphafold | PREDICTED | 80.09 | — |
Amino-acid sequence (649 residues)
MAPGEKIKAK IKKNLPVTGP QAPTIKELMR WYCLNTNTHG CRRIVVSRGR LRRLLWIGFT LTAVALILWQ CALLVFSFYT VSVSIKVHFR KLDFPAVTIC NINPYKYSTV RHLLADLEQE TREALKSLYG FPESRKRREA ESWNSVSEGK QPRFSHRIPL LIFDQDEKGK ARDFFTGRKR KVGGSIIHKA SNVMHIESKQ VVGFQLCSND TSDCATYTFS SGINAIQEWY KLHYMNIMAQ VPLEKKINMS YSAEELLVTC FFDGVSCDAR NFTLFHHPMH GNCYTFNNRE NETILSTSMG GSEYGLQVIL YINEEEYNPF LVSSTGAKVI IHRQDEYPFV EDVGTEIETA MVTSIGMHLT ESFKLSEPYS QCTEDGSDVP IRNIYNAAYS LQICLHSCFQ TKMVEKCGCA QYSQPLPPAA NYCNYQQHPN WMYCYYQLHR AFVQEELGCQ SVCKEACSFK EWTLTTSLAQ WPSVVSEKWL LPVLTWDQGR QVNKKLNKTD LAKLLIFYKD LNQRSIMESP ANSIEMLLSN FGGQLGLWMS CSVVCVIEII EVFFIDFFSI IARRQWQKAK EWWAWKQAPP CPEAPRSPQG QDNPALDIDD DLPTFNSALH LPPALGTQVP GTPPPKYNTL RLERAFSNQL TDTQMLDEL
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