About Epithelial sodium channel subunit delta
Epithelial sodium channel subunit delta (SCNN1D) is a protein
from Homo sapiens identified by UniProt accession
P51172, 802 residues long.
MolForge cross-references it against 0 known binders and
28 disease associations.
Target properties
| Protein name | Epithelial sodium channel subunit delta |
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| UniProt accession | P51172 |
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| Gene | SCNN1D |
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| Organism | Homo sapiens |
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| Length | 802 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Disease associations (28)
Diseases linked to this target (Open Targets).
- neurodegenerative disease · score 0.44
- neuroinflammatory disorder · score 0.24
- glioblastoma multiforme · score 0.18
- breast adenocarcinoma · score 0.16
- inflammatory bowel disease · score 0.11
- pulse pressure measurement · score 0.05
- intraocular pressure measurement · score 0.04
- myxedema · score 0.03
- drug use measurement · score 0.03
- reticulocyte count · score 0.02
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-P51172-F1 | alphafold | PREDICTED | 66.11 | — |
Amino-acid sequence (802 residues)
MRAVLSQKTT PLPRYLWPGH LSGPRRLTWS WCSDHRTPTC RELGSPHPTP CTGPARGWPR RGGGPCGFTS AGHVLCGYPL CLLSGPIQGC GTGLGDSSMA FLSRTSPVAA ASFQSRQEAR GSILLQSCQL PPQWLSTEAW TGEWKQPHGG ALTSRSPGPV APQRPCHLKG WQHRPTQHNA ACKQGQAAAQ TPPRPGPPSA PPPPPKEGHQ EGLVELPASF RELLTFFCTN ATIHGAIRLV CSRGNRLKTT SWGLLSLGAL VALCWQLGLL FERHWHRPVL MAVSVHSERK LLPLVTLCDG NPRRPSPVLR HLELLDEFAR ENIDSLYNVN LSKGRAALSA TVPRHEPPFH LDREIRLQRL SHSGSRVRVG FRLCNSTGGD CFYRGYTSGV AAVQDWYHFH YVDILALLPA AWEDSHGSQD GHFVLSCSYD GLDCQARQFR TFHHPTYGSC YTVDGVWTAQ RPGITHGVGL VLRVEQQPHL PLLSTLAGIR VMVHGRNHTP FLGHHSFSVR PGTEATISIR EDEVHRLGSP YGHCTAGGEG VEVELLHNTS YTRQACLVSC FQQLMVETCS CGYYLHPLPA GAEYCSSARH PAWGHCFYRL YQDLETHRLP CTSRCPRPCR ESAFKLSTGT SRWPSAKSAG WTLATLGEQG LPHQSHRQRS SLAKINIVYQ ELNYRSVEEA PVYSVPQLLS AMGSLCSLWF GASVLSLLEL LELLLDASAL TLVLGGRRLR RAWFSWPRAS PASGASSIKP EASQMPPPAG GTSDDPEPSG PHLPRVMLPG VLAGVSAEES WAGPQPLETL DT
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