About 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-1
1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-1 (PLCD1) is a protein
from Homo sapiens identified by UniProt accession
P51178, 756 residues long.
MolForge cross-references it against 0 known binders and
235 disease associations.
Target properties
| Protein name | 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-1 |
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| UniProt accession | P51178 |
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| Gene | PLCD1 |
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| Organism | Homo sapiens |
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| Length | 756 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Disease associations (235)
Diseases linked to this target (Open Targets).
- nonsyndromic congenital nail disorder 3 · score 0.58
- sitting height measurement · score 0.40
- leukonychia totalis · score 0.37
- skin appendage disorder · score 0.27
- Follicular Cyst · score 0.27
- endometrial cancer · score 0.23
- glioblastoma multiforme · score 0.23
- body height · score 0.22
- cutaneous melanoma · score 0.18
- breast adenocarcinoma · score 0.13
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-P51178-F1 | alphafold | PREDICTED | 89.12 | — |
Amino-acid sequence (756 residues)
MDSGRDFLTL HGLQDDEDLQ ALLKGSQLLK VKSSSWRRER FYKLQEDCKT IWQESRKVMR TPESQLFSIE DIQEVRMGHR TEGLEKFARD VPEDRCFSIV FKDQRNTLDL IAPSPADAQH WVLGLHKIIH HSGSMDQRQK LQHWIHSCLR KADKNKDNKM SFKELQNFLK ELNIQVDDSY ARKIFRECDH SQTDSLEDEE IEAFYKMLTQ RVEIDRTFAE AAGSGETLSV DQLVTFLQHQ QREEAAGPAL ALSLIERYEP SETAKAQRQM TKDGFLMYLL SADGSAFSLA HRRVYQDMGQ PLSHYLVSSS HNTYLLEDQL AGPSSTEAYI RALCKGCRCL ELDCWDGPNQ EPIIYHGYTF TSKILFCDVL RAIRDYAFKA SPYPVILSLE NHCTLEQQRV MARHLHAILG PMLLNRPLDG VTNSLPSPEQ LKGKILLKGK KLGGLLPPGG EGGPEATVVS DEDEAAEMED EAVRSRVQHK PKEDKLRLAQ ELSDMVIYCK SVHFGGFSSP GTPGQAFYEM ASFSENRALR LLQESGNGFV RHNVGHLSRI YPAGWRTDSS NYSPVEMWNG GCQIVALNFQ TPGPEMDVYQ GRFQDNGACG YVLKPAFLRD PNGTFNPRAL AQGPWWARKR LNIRVISGQQ LPKVNKNKNS IVDPKVTVEI HGVSRDVASR QTAVITNNGF NPWWDTEFAF EVVVPDLALI RFLVEDYDAS SKNDFIGQST IPLNSLKQGY RHVHLMSKNG DQHPSATLFV KISLQD
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