About Nuclear receptor ROR-gamma
Nuclear receptor ROR-gamma (RORC) is a protein
from Homo sapiens identified by UniProt accession
P51449, 518 residues long.
MolForge cross-references it against 0 known binders and
575 disease associations.
Target properties
| Protein name | Nuclear receptor ROR-gamma |
|---|
| UniProt accession | P51449 |
|---|
| Gene | RORC |
|---|
| Organism | Homo sapiens |
|---|
| Length | 518 residues |
|---|
| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
|---|
Approved drugs hitting this target (3)
DrugCentral-linked approved drugs that act on this protein.
Disease associations (575)
Diseases linked to this target (Open Targets).
- serum gamma-glutamyl transferase measurement · score 0.57
- ulcerative colitis · score 0.35
- inflammatory bowel disease · score 0.35
- asthma · score 0.31
- Eczematoid dermatitis · score 0.30
- allergic rhinitis · score 0.25
- psoriasis · score 0.25
- ankylosing spondylitis · score 0.25
- seasonal allergic rhinitis · score 0.25
- Crohn's disease · score 0.24
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-P51449-F1 | alphafold | PREDICTED | 74.16 | — |
Amino-acid sequence (518 residues)
MDRAPQRQHR ASRELLAAKK THTSQIEVIP CKICGDKSSG IHYGVITCEG CKGFFRRSQR CNAAYSCTRQ QNCPIDRTSR NRCQHCRLQK CLALGMSRDA VKFGRMSKKQ RDSLHAEVQK QLQQRQQQQQ EPVVKTPPAG AQGADTLTYT LGLPDGQLPL GSSPDLPEAS ACPPGLLKAS GSGPSYSNNL AKAGLNGASC HLEYSPERGK AEGRESFYST GSQLTPDRCG LRFEEHRHPG LGELGQGPDS YGSPSFRSTP EAPYASLTEI EHLVQSVCKS YRETCQLRLE DLLRQRSNIF SREEVTGYQR KSMWEMWERC AHHLTEAIQY VVEFAKRLSG FMELCQNDQI VLLKAGAMEV VLVRMCRAYN ADNRTVFFEG KYGGMELFRA LGCSELISSI FDFSHSLSAL HFSEDEIALY TALVLINAHR PGLQEKRKVE QLQYNLELAF HHHLCKTHRQ SILAKLPPKG KLRSLCSQHV ERLQIFQHLH PIVVQAAFPP LYKELFSTET ESPVGLSK
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