About Tyrosine-protein kinase Blk
Tyrosine-protein kinase Blk (BLK) is a protein
from Homo sapiens identified by UniProt accession
P51451, 505 residues long.
MolForge cross-references it against 0 known binders and
302 disease associations.
Target properties
| Protein name | Tyrosine-protein kinase Blk |
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| UniProt accession | P51451 |
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| Gene | BLK |
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| Organism | Homo sapiens |
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| Length | 505 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Approved drugs hitting this target (16)
DrugCentral-linked approved drugs that act on this protein.
Disease associations (302)
Diseases linked to this target (Open Targets).
- systemic lupus erythematosus · score 0.64
- chronic myelogenous leukemia · score 0.60
- acute lymphoblastic leukemia · score 0.56
- MODY · score 0.55
- mucocutaneous lymph node syndrome · score 0.50
- lymphoid leukemia · score 0.45
- systemic scleroderma · score 0.45
- multiple myeloma · score 0.43
- neoplasm · score 0.42
- rheumatoid arthritis · score 0.42
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-P51451-F1 | alphafold | PREDICTED | 81.55 | — |
Amino-acid sequence (505 residues)
MGLVSSKKPD KEKPIKEKDK GQWSPLKVSA QDKDAPPLPP LVVFNHLTPP PPDEHLDEDK HFVVALYDYT AMNDRDLQML KGEKLQVLKG TGDWWLARSL VTGREGYVPS NFVARVESLE MERWFFRSQG RKEAERQLLA PINKAGSFLI RESETNKGAF SLSVKDVTTQ GELIKHYKIR CLDEGGYYIS PRITFPSLQA LVQHYSKKGD GLCQRLTLPC VRPAPQNPWA QDEWEIPRQS LRLVRKLGSG QFGEVWMGYY KNNMKVAIKT LKEGTMSPEA FLGEANVMKA LQHERLVRLY AVVTKEPIYI VTEYMARGCL LDFLKTDEGS RLSLPRLIDM SAQIAEGMAY IERMNSIHRD LRAANILVSE ALCCKIADFG LARIIDSEYT AQEGAKFPIK WTAPEAIHFG VFTIKADVWS FGVLLMEVVT YGRVPYPGMS NPEVIRNLER GYRMPRPDTC PPELYRGVIA ECWRSRPEER PTFEFLQSVL EDFYTATERQ YELQP
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