About Dual specificity protein phosphatase 3
Dual specificity protein phosphatase 3 (DUSP3) is a protein
from Homo sapiens identified by UniProt accession
P51452, 185 residues long.
MolForge cross-references it against 0 known binders and
92 disease associations.
Target properties
| Protein name | Dual specificity protein phosphatase 3 |
|---|
| UniProt accession | P51452 |
|---|
| Gene | DUSP3 |
|---|
| Organism | Homo sapiens |
|---|
| Length | 185 residues |
|---|
| Molecular weight | — |
|---|
| EC numbers | — |
|---|
| Target class | UNCLASSIFIED |
|---|
| Subcellular location | — |
|---|
| Keywords | — |
|---|
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
|---|
Disease associations (92)
Diseases linked to this target (Open Targets).
- bone fracture · score 0.15
- heel bone mineral density · score 0.14
- high density lipoprotein cholesterol measurement · score 0.13
- bone quantitative ultrasound measurement · score 0.12
- endometrial cancer · score 0.12
- alcohol drinking · score 0.11
- hip bone mineral density · score 0.11
- femoral neck bone mineral density · score 0.10
- Drugs affecting bone structure and mineralization use measurement · score 0.10
- bone density · score 0.09
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-P51452-F1 | alphafold | PREDICTED | 95.88 | — |
Amino-acid sequence (185 residues)
MSGSFELSVQ DLNDLLSDGS GCYSLPSQPC NEVTPRIYVG NASVAQDIPK LQKLGITHVL NAAEGRSFMH VNTNANFYKD SGITYLGIKA NDTQEFNLSA YFERAADFID QALAQKNGRV LVHCREGYSR SPTLVIAYLM MRQKMDVKSA LSIVRQNREI GPNDGFLAQL CQLNDRLAKE GKLKP
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