About Insulin-like 3
Insulin-like 3 (INSL3) is a protein
from Homo sapiens identified by UniProt accession
P51460, 131 residues long.
MolForge cross-references it against 0 known binders and
264 disease associations.
Target properties
| Protein name | Insulin-like 3 |
|---|
| UniProt accession | P51460 |
|---|
| Gene | INSL3 |
|---|
| Organism | Homo sapiens |
|---|
| Length | 131 residues |
|---|
| Molecular weight | — |
|---|
| EC numbers | — |
|---|
| Target class | UNCLASSIFIED |
|---|
| Subcellular location | — |
|---|
| Keywords | — |
|---|
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
|---|
Disease associations (264)
Diseases linked to this target (Open Targets).
- cryptorchidism · score 0.70
- genetic disorder · score 0.33
- cutaneous melanoma · score 0.18
- breast adenocarcinoma · score 0.17
- squamous cell lung carcinoma · score 0.12
- gastric adenocarcinoma · score 0.12
- azoospermia · score 0.09
- partial chromosome Y deletion · score 0.09
- male infertility with teratozoospermia due to single gene mutation · score 0.08
- isolated congenital hypogonadotropic hypogonadism · score 0.08
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-P51460-F1 | alphafold | PREDICTED | 66.10 | — |
Amino-acid sequence (131 residues)
MDPRLPAWAL VLLGPALVFA LGPAPTPEMR EKLCGHHFVR ALVRVCGGPR WSTEARRPAT GGDRELLQWL ERRHLLHGLV ADSNLTLGPG LQPLPQTSHH HRHHRAAATN PARYCCLSGC TQQDLLTLCP Y
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