About Matrix metalloproteinase-15
Matrix metalloproteinase-15 (MMP15) is a protein
from Homo sapiens identified by UniProt accession
P51511, 669 residues long.
MolForge cross-references it against 0 known binders and
127 disease associations.
Target properties
| Protein name | Matrix metalloproteinase-15 |
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| UniProt accession | P51511 |
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| Gene | MMP15 |
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| Organism | Homo sapiens |
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| Length | 669 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Disease associations (127)
Diseases linked to this target (Open Targets).
- serum gamma-glutamyl transferase measurement · score 0.44
- serum alanine aminotransferase measurement · score 0.43
- FEV/FVC ratio · score 0.41
- chronic obstructive pulmonary disease · score 0.31
- pulmonary function measurement · score 0.29
- aspartate aminotransferase measurement · score 0.29
- neurodegenerative disease · score 0.26
- smoking behaviour measurement · score 0.24
- Cholestasis · score 0.23
- congenital heart disease · score 0.23
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-P51511-F1 | alphafold | PREDICTED | 73.73 | — |
Amino-acid sequence (669 residues)
MGSDPSAPGR PGWTGSLLGD REEAARPRLL PLLLVLLGCL GLGVAAEDAE VHAENWLRLY GYLPQPSRHM STMRSAQILA SALAEMQRFY GIPVTGVLDE ETKEWMKRPR CGVPDQFGVR VKANLRRRRK RYALTGRKWN NHHLTFSIQN YTEKLGWYHS MEAVRRAFRV WEQATPLVFQ EVPYEDIRLR RQKEADIMVL FASGFHGDSS PFDGTGGFLA HAYFPGPGLG GDTHFDADEP WTFSSTDLHG NNLFLVAVHE LGHALGLEHS SNPNAIMAPF YQWKDVDNFK LPEDDLRGIQ QLYGTPDGQP QPTQPLPTVT PRRPGRPDHR PPRPPQPPPP GGKPERPPKP GPPVQPRATE RPDQYGPNIC DGDFDTVAML RGEMFVFKGR WFWRVRHNRV LDNYPMPIGH FWRGLPGDIS AAYERQDGRF VFFKGDRYWL FREANLEPGY PQPLTSYGLG IPYDRIDTAI WWEPTGHTFF FQEDRYWRFN EETQRGDPGY PKPISVWQGI PASPKGAFLS NDAAYTYFYK GTKYWKFDNE RLRMEPGYPK SILRDFMGCQ EHVEPGPRWP DVARPPFNPH GGAEPGADSA EGDVGDGDGD FGAGVNKDGG SRVVVQMEEV ARTVNVVMVL VPLLLLLCVL GLTYALVQMQ RKGAPRVLLY CKRSLQEWV
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