About Matrix metalloproteinase-16
Matrix metalloproteinase-16 (MMP16) is a protein
from Homo sapiens identified by UniProt accession
P51512, 607 residues long.
MolForge cross-references it against 0 known binders and
170 disease associations.
Target properties
| Protein name | Matrix metalloproteinase-16 |
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| UniProt accession | P51512 |
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| Gene | MMP16 |
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| Organism | Homo sapiens |
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| Length | 607 residues |
|---|
| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
|---|
Disease associations (170)
Diseases linked to this target (Open Targets).
- schizophrenia · score 0.49
- BMI-adjusted waist-hip ratio · score 0.41
- heel bone mineral density · score 0.41
- appendicular lean mass · score 0.39
- BMI-adjusted waist circumference · score 0.37
- neurodegenerative disease · score 0.34
- body mass index · score 0.32
- neurofibrillary tangles measurement · score 0.31
- Abnormality of refraction · score 0.30
- anorexia nervosa · score 0.29
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-P51512-F1 | alphafold | PREDICTED | 76.68 | — |
Amino-acid sequence (607 residues)
MILLTFSTGR RLDFVHHSGV FFLQTLLWIL CATVCGTEQY FNVEVWLQKY GYLPPTDPRM SVLRSAETMQ SALAAMQQFY GINMTGKVDR NTIDWMKKPR CGVPDQTRGS SKFHIRRKRY ALTGQKWQHK HITYSIKNVT PKVGDPETRK AIRRAFDVWQ NVTPLTFEEV PYSELENGKR DVDITIIFAS GFHGDSSPFD GEGGFLAHAY FPGPGIGGDT HFDSDEPWTL GNPNHDGNDL FLVAVHELGH ALGLEHSNDP TAIMAPFYQY METDNFKLPN DDLQGIQKIY GPPDKIPPPT RPLPTVPPHR SIPPADPRKN DRPKPPRPPT GRPSYPGAKP NICDGNFNTL AILRREMFVF KDQWFWRVRN NRVMDGYPMQ ITYFWRGLPP SIDAVYENSD GNFVFFKGNK YWVFKDTTLQ PGYPHDLITL GSGIPPHGID SAIWWEDVGK TYFFKGDRYW RYSEEMKTMD PGYPKPITVW KGIPESPQGA FVHKENGFTY FYKGKEYWKF NNQILKVEPG YPRSILKDFM GCDGPTDRVK EGHSPPDDVD IVIKLDNTAS TVKAIAIVIP CILALCLLVL VYTVFQFKRK GTPRHILYCK RSMQEWV
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