RNA-binding protein Nova-1 (NOVA1)

About RNA-binding protein Nova-1

RNA-binding protein Nova-1 (NOVA1) is a protein from Homo sapiens identified by UniProt accession P51513, 507 residues long. MolForge cross-references it against 0 known binders and 114 disease associations.

Target properties

Protein name	RNA-binding protein Nova-1
UniProt accession	P51513
Gene	NOVA1
Organism	Homo sapiens
Length	507 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (114)

Diseases linked to this target (Open Targets).

self reported educational attainment · score 0.48
cognitive function measurement · score 0.42
cortical surface area measurement · score 0.31
mathematical ability · score 0.31
lifestyle measurement · score 0.31
sleep duration · score 0.31
intelligence · score 0.31
sodium measurement · score 0.29
age at first birth measurement · score 0.27
brain measurement · score 0.25

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-P51513-F1	alphafold	PREDICTED	62.66	—

Amino-acid sequence (507 residues)

MMAAAPIQQN GTHTGVPIDL DPPDSRKRPL EAPPEAGSTK RTNTGEDGQY FLKVLIPSYA AGSIIGKGGQ TIVQLQKETG ATIKLSKSKD FYPGTTERVC LIQGTVEALN AVHGFIAEKI REMPQNVAKT EPVSILQPQT TVNPDRIKQT LPSSPTTTKS SPSDPMTTSR ANQVKIIVPN STAGLIIGKG GATVKAVMEQ SGAWVQLSQK PDGINLQERV VTVSGEPEQN RKAVELIIQK IQEDPQSGSC LNISYANVTG PVANSNPTGS PYANTAEVLP TAAAAAGLLG HANLAGVAAF PAVLSGFTGN DLVAITSALN TLASYGYNLN TLGLGLSQAA ATGALAAAAA SANPAAAAAN LLATYASEAS ASGSTAGGTA GTFALGSLAA ATAATNGYFG AASPLAASAI LGTEKSTDGS KDVVEIAVPE NLVGAILGKG GKTLVEYQEL TGARIQISKK GEFVPGTRNR KVTITGTPAA TQAAQYLITQ RITYEQGVRA ANPQKVG

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards