About Isocitrate dehydrogenase [NAD] subunit gamma, mitochondrial
Isocitrate dehydrogenase [NAD] subunit gamma, mitochondrial (IDH3G) is a protein
from Homo sapiens identified by UniProt accession
P51553, 393 residues long.
MolForge cross-references it against 0 known binders and
20 disease associations.
Target properties
| Protein name | Isocitrate dehydrogenase [NAD] subunit gamma, mitochondrial |
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| UniProt accession | P51553 |
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| Gene | IDH3G |
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| Organism | Homo sapiens |
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| Length | 393 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Disease associations (20)
Diseases linked to this target (Open Targets).
- neurodegenerative disease · score 0.35
- Spastic tetraplegia · score 0.12
- neuronal ceroid lipofuscinosis 1 · score 0.04
- familial isolated congenital asplenia · score 0.04
- neoplasm · score 0.01
- achalasia-alacrima syndrome · score 0.01
- glioblastoma multiforme · score 0.01
- nonpapillary renal cell carcinoma · score 0.01
- gonorrhea · score 0.00
- acute myeloid leukemia · score 0.00
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-P51553-F1 | alphafold | PREDICTED | 88.65 | — |
Amino-acid sequence (393 residues)
MALKVATVAG SAAKAVLGPA LLCRPWEVLG AHEVPSRNIF SEQTIPPSAK YGGRHTVTMI PGDGIGPELM LHVKSVFRHA CVPVDFEEVH VSSNADEEDI RNAIMAIRRN RVALKGNIET NHNLPPSHKS RNNILRTSLD LYANVIHCKS LPGVVTRHKD IDILIVRENT EGEYSSLEHE SVAGVVESLK IITKAKSLRI AEYAFKLAQE SGRKKVTAVH KANIMKLGDG LFLQCCREVA ARYPQITFEN MIVDNTTMQL VSRPQQFDVM VMPNLYGNIV NNVCAGLVGG PGLVAGANYG HVYAVFETAT RNTGKSIANK NIANPTATLL ASCMMLDHLK LHSYATSIRK AVLASMDNEN MHTPDIGGQG TTSEAIQDVI RHIRVINGRA VEA
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