Galactokinase (GALK1)

About Galactokinase

Galactokinase (GALK1) is a protein from Homo sapiens identified by UniProt accession P51570, 392 residues long. MolForge cross-references it against 0 known binders and 104 disease associations.

Target properties

Protein name	Galactokinase
UniProt accession	P51570
Gene	GALK1
Organism	Homo sapiens
Length	392 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (104)

Diseases linked to this target (Open Targets).

galactokinase deficiency · score 0.85
junctional epidermolysis bullosa with pyloric atresia · score 0.53
Junctional epidermolysis bullosa - pyloric atresia · score 0.53
epidermolysis bullosa, junctional 5A, intermediate · score 0.47
Localized epidermolysis bullosa simplex · score 0.35
junctional epidermolysis bullosa, non-Herlitz type · score 0.35
epidermolysis bullosa simplex 1C, localized · score 0.35
Red cell distribution width · score 0.26
genetic disorder · score 0.19
sex hormone-binding globulin measurement · score 0.14

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-P51570-F1	alphafold	PREDICTED	97.19	—

Amino-acid sequence (392 residues)

MAALRQPQVA ELLAEARRAF REEFGAEPEL AVSAPGRVNL IGEHTDYNQG LVLPMALELM TVLVGSPRKD GLVSLLTTSE GADEPQRLQF PLPTAQRSLE PGTPRWANYV KGVIQYYPAA PLPGFSAVVV SSVPLGGGLS SSASLEVATY TFLQQLCPDS GTIAARAQVC QQAEHSFAGM PCGIMDQFIS LMGQKGHALL IDCRSLETSL VPLSDPKLAV LITNSNVRHS LASSEYPVRR RQCEEVARAL GKESLREVQL EELEAARDLV SKEGFRRARH VVGEIRRTAQ AAAALRRGDY RAFGRLMVES HRSLRDDYEV SCPELDQLVE AALAVPGVYG SRMTGGGFGG CTVTLLEASA APHAMRHIQE HYGGTATFYL SQAADGAKVL CL

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards