About Thiopurine S-methyltransferase
Thiopurine S-methyltransferase (TPMT) is a protein
from Homo sapiens identified by UniProt accession
P51580, 245 residues long.
MolForge cross-references it against 0 known binders and
150 disease associations.
Target properties
| Protein name | Thiopurine S-methyltransferase |
|---|
| UniProt accession | P51580 |
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| Gene | TPMT |
|---|
| Organism | Homo sapiens |
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| Length | 245 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
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| Max clinical phase | — |
|---|
Approved drugs hitting this target (2)
DrugCentral-linked approved drugs that act on this protein.
Disease associations (150)
Diseases linked to this target (Open Targets).
- thiopurine S-methyltransferase deficiency · score 0.51
- neurodegenerative disease · score 0.43
- inborn errors of metabolism · score 0.37
- cancer · score 0.29
- thiopurine metabolite measurement · score 0.26
- protein measurement · score 0.23
- thiopurine methyltransferase activity measurement · score 0.22
- neuroinflammatory disorder · score 0.16
- atrial fibrillation · score 0.11
- myelosuppression · score 0.08
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-P51580-F1 | alphafold | PREDICTED | 94.97 | — |
Amino-acid sequence (245 residues)
MDGTRTSLDI EEYSDTEVQK NQVLTLEEWQ DKWVNGKTAF HQEQGHQLLK KHLDTFLKGK SGLRVFFPLC GKAVEMKWFA DRGHSVVGVE ISELGIQEFF TEQNLSYSEE PITEIPGTKV FKSSSGNISL YCCSIFDLPR TNIGKFDMIW DRGALVAINP GDRKCYADTM FSLLGKKFQY LLCVLSYDPT KHPGPPFYVP HAEIERLFGK ICNIRCLEKV DAFEERHKSW GIDCLFEKLY LLTEK
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