About Methyl-CpG-binding protein 2
Methyl-CpG-binding protein 2 (MECP2) is a protein
from Homo sapiens identified by UniProt accession
P51608, 486 residues long.
MolForge cross-references it against 0 known binders and
946 disease associations.
Target properties
| Protein name | Methyl-CpG-binding protein 2 |
|---|
| UniProt accession | P51608 |
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| Gene | MECP2 |
|---|
| Organism | Homo sapiens |
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| Length | 486 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
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| Max clinical phase | — |
|---|
Disease associations (946)
Diseases linked to this target (Open Targets).
- Rett syndrome · score 0.89
- X-linked intellectual disability-psychosis-macroorchidism syndrome · score 0.82
- severe neonatal-onset encephalopathy with microcephaly · score 0.80
- syndromic X-linked intellectual disability Lubs type · score 0.76
- X-linked intellectual disability - psychosis - macroorchidism · score 0.74
- Angelman syndrome · score 0.68
- X-linked syndromic intellectual disability · score 0.57
- genetic disorder · score 0.56
- Intellectual disability · score 0.54
- Neurodevelopmental delay · score 0.52
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-P51608-F1 | alphafold | PREDICTED | 56.60 | — |
Amino-acid sequence (486 residues)
MVAGMLGLRE EKSEDQDLQG LKDKPLKFKK VKKDKKEEKE GKHEPVQPSA HHSAEPAEAG KAETSEGSGS APAVPEASAS PKQRRSIIRD RGPMYDDPTL PEGWTRKLKQ RKSGRSAGKY DVYLINPQGK AFRSKVELIA YFEKVGDTSL DPNDFDFTVT GRGSPSRREQ KPPKKPKSPK APGTGRGRGR PKGSGTTRPK AATSEGVQVK RVLEKSPGKL LVKMPFQTSP GGKAEGGGAT TSTQVMVIKR PGRKRKAEAD PQAIPKKRGR KPGSVVAAAA AEAKKKAVKE SSIRSVQETV LPIKKRKTRE TVSIEVKEVV KPLLVSTLGE KSGKGLKTCK SPGRKSKESS PKGRSSSASS PPKKEHHHHH HHSESPKAPV PLLPPLPPPP PEPESSEDPT SPPEPQDLSS SVCKEEKMPR GGSLESDGCP KEPAKTQPAV ATAATAAEKY KHRGEGERKD IVSSSMPRPN REEPVDSRTP VTERVS
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