About Aldehyde dehydrogenase family 3 member A2
Aldehyde dehydrogenase family 3 member A2 (ALDH3A2) is a protein
from Homo sapiens identified by UniProt accession
P51648, 485 residues long.
MolForge cross-references it against 0 known binders and
96 disease associations.
Target properties
| Protein name | Aldehyde dehydrogenase family 3 member A2 |
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| UniProt accession | P51648 |
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| Gene | ALDH3A2 |
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| Organism | Homo sapiens |
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| Length | 485 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Disease associations (96)
Diseases linked to this target (Open Targets).
- Sjogren-Larsson syndrome · score 0.82
- Sjögren-Larsson syndrome · score 0.82
- mean platelet volume · score 0.40
- cerebral palsy · score 0.34
- neurodegenerative disease · score 0.19
- genetic disorder · score 0.19
- neoplasm · score 0.09
- nonpapillary renal cell carcinoma · score 0.08
- creatinine measurement · score 0.07
- mean corpuscular hemoglobin · score 0.06
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-P51648-F1 | alphafold | PREDICTED | 96.64 | — |
Amino-acid sequence (485 residues)
MELEVRRVRQ AFLSGRSRPL RFRLQQLEAL RRMVQEREKD ILTAIAADLC KSEFNVYSQE VITVLGEIDF MLENLPEWVT AKPVKKNVLT MLDEAYIQPQ PLGVVLIIGA WNYPFVLTIQ PLIGAIAAGN AVIIKPSELS ENTAKILAKL LPQYLDQDLY IVINGGVEET TELLKQRFDH IFYTGNTAVG KIVMEAAAKH LTPVTLELGG KSPCYIDKDC DLDIVCRRIT WGKYMNCGQT CIAPDYILCE ASLQNQIVWK IKETVKEFYG ENIKESPDYE RIINLRHFKR ILSLLEGQKI AFGGETDEAT RYIAPTVLTD VDPKTKVMQE EIFGPILPIV PVKNVDEAIN FINEREKPLA LYVFSHNHKL IKRMIDETSS GGVTGNDVIM HFTLNSFPFG GVGSSGMGAY HGKHSFDTFS HQRPCLLKSL KREGANKLRY PPNSQSKVDW GKFFLLKRFN KEKLGLLLLT FLGIVAAVLV KAEYY
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