About Succinate-semialdehyde dehydrogenase, mitochondrial
Succinate-semialdehyde dehydrogenase, mitochondrial (ALDH5A1) is a protein
from Homo sapiens identified by UniProt accession
P51649, 535 residues long.
MolForge cross-references it against 0 known binders and
328 disease associations.
Target properties
| Protein name | Succinate-semialdehyde dehydrogenase, mitochondrial |
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| UniProt accession | P51649 |
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| Gene | ALDH5A1 |
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| Organism | Homo sapiens |
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| Length | 535 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Approved drugs hitting this target (1)
DrugCentral-linked approved drugs that act on this protein.
Disease associations (328)
Diseases linked to this target (Open Targets).
- succinic semialdehyde dehydrogenase deficiency · score 0.84
- Seizure · score 0.62
- epilepsy · score 0.61
- bipolar disorder · score 0.61
- unipolar depression · score 0.59
- migraine disorder · score 0.58
- bipolar I disorder · score 0.57
- schizophrenia · score 0.56
- alkaline phosphatase measurement · score 0.55
- genetic disorder · score 0.52
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-P51649-F1 | alphafold | PREDICTED | 91.91 | — |
Amino-acid sequence (535 residues)
MATCIWLRSC GARRLGSTFP GCRLRPRAGG LVPASGPAPG PAQLRCYAGR LAGLSAALLR TDSFVGGRWL PAAATFPVQD PASGAALGMV ADCGVREARA AVRAAYEAFC RWREVSAKER SSLLRKWYNL MIQNKDDLAR IITAESGKPL KEAHGEILYS AFFLEWFSEE ARRVYGDIIH TPAKDRRALV LKQPIGVAAV ITPWNFPSAM ITRKVGAALA AGCTVVVKPA EDTPFSALAL AELASQAGIP SGVYNVIPCS RKNAKEVGEA ICTDPLVSKI SFTGSTTTGK ILLHHAANSV KRVSMELGGL APFIVFDSAN VDQAVAGAMA SKFRNTGQTC VCSNQFLVQR GIHDAFVKAF AEAMKKNLRV GNGFEEGTTQ GPLINEKAVE KVEKQVNDAV SKGATVVTGG KRHQLGKNFF EPTLLCNVTQ DMLCTHEETF GPLAPVIKFD TEEEAIAIAN AADVGLAGYF YSQDPAQIWR VAEQLEVGMV GVNEGLISSV ECPFGGVKQS GLGREGSKYG IDEYLELKYV CYGGL
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