Glypican-3 (GPC3)

About Glypican-3

Glypican-3 (GPC3) is a protein from Homo sapiens identified by UniProt accession P51654, 580 residues long. MolForge cross-references it against 0 known binders and 621 disease associations.

Target properties

Protein name	Glypican-3
UniProt accession	P51654
Gene	GPC3
Organism	Homo sapiens
Length	580 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (621)

Diseases linked to this target (Open Targets).

Wilms tumor 1 · score 0.71
Simpson-Golabi-Behmel syndrome · score 0.71
COVID-19 · score 0.54
genetic disorder · score 0.46
kidney neoplasm · score 0.37
pancreatic ductal adenocarcinoma · score 0.37
Polydactyly · score 0.37
pancreatic carcinoma · score 0.37
bile duct carcinoma · score 0.37
prostate adenocarcinoma · score 0.37

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-P51654-F1	alphafold	PREDICTED	75.08	—

Amino-acid sequence (580 residues)

MAGTVRTACL VVAMLLSLDF PGQAQPPPPP PDATCHQVRS FFQRLQPGLK WVPETPVPGS DLQVCLPKGP TCCSRKMEEK YQLTARLNME QLLQSASMEL KFLIIQNAAV FQEAFEIVVR HAKNYTNAMF KNNYPSLTPQ AFEFVGEFFT DVSLYILGSD INVDDMVNEL FDSLFPVIYT QLMNPGLPDS ALDINECLRG ARRDLKVFGN FPKLIMTQVS KSLQVTRIFL QALNLGIEVI NTTDHLKFSK DCGRMLTRMW YCSYCQGLMM VKPCGGYCNV VMQGCMAGVV EIDKYWREYI LSLEELVNGM YRIYDMENVL LGLFSTIHDS IQYVQKNAGK LTTTIGKLCA HSQQRQYRSA YYPEDLFIDK KVLKVAHVEH EETLSSRRRE LIQKLKSFIS FYSALPGYIC SHSPVAENDT LCWNGQELVE RYSQKAARNG MKNQFNLHEL KMKGPEPVVS QIIDKLKHIN QLLRTMSMPK GRVLDKNLDE EGFESGDCGD DEDECIGGSG DGMIKVKNQL RFLAELAYDL DVDDAPGNSQ QATPKDNEIS TFHNLGNVHS PLKLLTSMAI SVVCFFFLVH

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards