About Peroxisomal multifunctional enzyme type 2
Peroxisomal multifunctional enzyme type 2 (HSD17B4) is a protein
from Homo sapiens identified by UniProt accession
P51659, 736 residues long.
MolForge cross-references it against 0 known binders and
165 disease associations.
Target properties
| Protein name | Peroxisomal multifunctional enzyme type 2 |
|---|
| UniProt accession | P51659 |
|---|
| Gene | HSD17B4 |
|---|
| Organism | Homo sapiens |
|---|
| Length | 736 residues |
|---|
| Molecular weight | — |
|---|
| EC numbers | — |
|---|
| Target class | UNCLASSIFIED |
|---|
| Subcellular location | — |
|---|
| Keywords | — |
|---|
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
|---|
Disease associations (165)
Diseases linked to this target (Open Targets).
- d-bifunctional protein deficiency · score 0.84
- Perrault syndrome 1 · score 0.75
- Perrault syndrome · score 0.72
- genetic disorder · score 0.49
- Perrault syndrome 2 · score 0.37
- hearing loss · score 0.37
- neurofibrillary tangles measurement · score 0.30
- neurodegenerative disease · score 0.29
- Abnormality of the nervous system · score 0.27
- Rare genetic deafness · score 0.27
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-P51659-F1 | alphafold | PREDICTED | 88.99 | — |
Amino-acid sequence (736 residues)
MGSPLRFDGR VVLVTGAGAG LGRAYALAFA ERGALVVVND LGGDFKGVGK GSLAADKVVE EIRRRGGKAV ANYDSVEEGE KVVKTALDAF GRIDVVVNNA GILRDRSFAR ISDEDWDIIH RVHLRGSFQV TRAAWEHMKK QKYGRIIMTS SASGIYGNFG QANYSAAKLG LLGLANSLAI EGRKSNIHCN TIAPNAGSRM TQTVMPEDLV EALKPEYVAP LVLWLCHESC EENGGLFEVG AGWIGKLRWE RTLGAIVRQK NHPMTPEAVK ANWKKICDFE NASKPQSIQE STGSIIEVLS KIDSEGGVSA NHTSRATSTA TSGFAGAIGQ KLPPFSYAYT ELEAIMYALG VGASIKDPKD LKFIYEGSSD FSCLPTFGVI IGQKSMMGGG LAEIPGLSIN FAKVLHGEQY LELYKPLPRA GKLKCEAVVA DVLDKGSGVV IIMDVYSYSE KELICHNQFS LFLVGSGGFG GKRTSDKVKV AVAIPNRPPD AVLTDTTSLN QAALYRLSGD WNPLHIDPNF ASLAGFDKPI LHGLCTFGFS ARRVLQQFAD NDVSRFKAIK ARFAKPVYPG QTLQTEMWKE GNRIHFQTKV QETGDIVISN AYVDLAPTSG TSAKTPSEGG KLQSTFVFEE IGRRLKDIGP EVVKKVNAVF EWHITKGGNI GAKWTIDLKS GSGKVYQGPA KGAADTTIIL SDEDFMEVVL GKLDPQKAFF SGRLKARGNI MLSQKLQMIL KDYAKL
Explore Peroxisomal multifunctional enzyme type 2 with MolForge
Find binders, run structure-based screening, and map this target across
diseases and approved drugs with our AI-powered platform.
Browse all targets