Neuronal membrane glycoprotein M6-a (GPM6A)

About Neuronal membrane glycoprotein M6-a

Neuronal membrane glycoprotein M6-a (GPM6A) is a protein from Homo sapiens identified by UniProt accession P51674, 278 residues long. MolForge cross-references it against 0 known binders and 94 disease associations.

Target properties

Protein name	Neuronal membrane glycoprotein M6-a
UniProt accession	P51674
Gene	GPM6A
Organism	Homo sapiens
Length	278 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (94)

Diseases linked to this target (Open Targets).

schizophrenia · score 0.52
self reported educational attainment · score 0.49
mathematical ability · score 0.43
smoking status measurement · score 0.42
neuroticism measurement · score 0.41
PHF-tau measurement · score 0.37
cognitive function measurement · score 0.31
intelligence · score 0.30
verbal-numerical reasoning measurement · score 0.28
mood disorder · score 0.26

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-P51674-F1	alphafold	PREDICTED	82.72	—

Amino-acid sequence (278 residues)

MEENMEEGQT QKGCFECCIK CLGGIPYASL IATILLYAGV ALFCGCGHEA LSGTVNILQT YFEMARTAGD TLDVFTMIDI FKYVIYGIAA AFFVYGILLM VEGFFTTGAI KDLYGDFKIT TCGRCVSAWF IMLTYLFMLA WLGVTAFTSL PVYMYFNLWT ICRNTTLVEG ANLCLDLRQF GIVTIGEEKK ICTVSENFLR MCESTELNMT FHLFIVALAG AGAAVIAMVH YLMVLSANWA YVKDACRMQK YEDIKSKEEQ ELHDIHSTRS KERLNAYT

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards