C-C chemokine receptor type 3 (CCR3)

About C-C chemokine receptor type 3

C-C chemokine receptor type 3 (CCR3) is a protein from Homo sapiens identified by UniProt accession P51677, 355 residues long. MolForge cross-references it against 0 known binders and 375 disease associations.

Target properties

Protein name	C-C chemokine receptor type 3
UniProt accession	P51677
Gene	CCR3
Organism	Homo sapiens
Length	355 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (375)

Diseases linked to this target (Open Targets).

eosinophil count · score 0.51
eosinophil percentage of leukocytes · score 0.39
neurodegenerative disease · score 0.35
celiac disease · score 0.33
basophil count · score 0.33
blood protein measurement · score 0.32
monocyte count · score 0.28
Behcet's syndrome · score 0.28
heel bone mineral density · score 0.27
glioblastoma multiforme · score 0.27

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-P51677-F1	alphafold	PREDICTED	83.42	—

Amino-acid sequence (355 residues)

MTTSLDTVET FGTTSYYDDV GLLCEKADTR ALMAQFVPPL YSLVFTVGLL GNVVVVMILI KYRRLRIMTN IYLLNLAISD LLFLVTLPFW IHYVRGHNWV FGHGMCKLLS GFYHTGLYSE IFFIILLTID RYLAIVHAVF ALRARTVTFG VITSIVTWGL AVLAALPEFI FYETEELFEE TLCSALYPED TVYSWRHFHT LRMTIFCLVL PLLVMAICYT GIIKTLLRCP SKKKYKAIRL IFVIMAVFFI FWTPYNVAIL LSSYQSILFG NDCERSKHLD LVMLVTEVIA YSHCCMNPVI YAFVGERFRK YLRHFFHRHL LMHLGRYIPF LPSEKLERTS SVSPSTAEPE LSIVF

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards