C-C chemokine receptor type 6 (CCR6)

About C-C chemokine receptor type 6

C-C chemokine receptor type 6 (CCR6) is a protein from Homo sapiens identified by UniProt accession P51684, 374 residues long. MolForge cross-references it against 0 known binders and 368 disease associations.

Target properties

Protein name	C-C chemokine receptor type 6
UniProt accession	P51684
Gene	CCR6
Organism	Homo sapiens
Length	374 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (368)

Diseases linked to this target (Open Targets).

rheumatoid arthritis · score 0.47
eosinophil count · score 0.41
neurodegenerative disease · score 0.37
ACPA-positive rheumatoid arthritis · score 0.37
Immunosuppressant use measurement · score 0.36
serum non-albumin protein measurement · score 0.35
primary biliary cirrhosis · score 0.30
total blood protein measurement · score 0.29
albumin:globulin ratio measurement · score 0.28
eosinophil percentage of leukocytes · score 0.28

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-P51684-F1	alphafold	PREDICTED	79.59	—

Amino-acid sequence (374 residues)

MSGESMNFSD VFDSSEDYFV SVNTSYYSVD SEMLLCSLQE VRQFSRLFVP IAYSLICVFG LLGNILVVIT FAFYKKARSM TDVYLLNMAI ADILFVLTLP FWAVSHATGA WVFSNATCKL LKGIYAINFN CGMLLLTCIS MDRYIAIVQA TKSFRLRSRT LPRSKIICLV VWGLSVIISS STFVFNQKYN TQGSDVCEPK YQTVSEPIRW KLLMLGLELL FGFFIPLMFM IFCYTFIVKT LVQAQNSKRH KAIRVIIAVV LVFLACQIPH NMVLLVTAAN LGKMNRSCQS EKLIGYTKTV TEVLAFLHCC LNPVLYAFIG QKFRNYFLKI LKDLWCVRRK YKSSGFSCAG RYSENISRQT SETADNDNAS SFTM

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards