About Arylsulfatase L
Arylsulfatase L (ARSL) is a protein
from Homo sapiens identified by UniProt accession
P51690, 589 residues long.
MolForge cross-references it against 0 known binders and
109 disease associations.
Target properties
| Protein name | Arylsulfatase L |
|---|
| UniProt accession | P51690 |
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| Gene | ARSL |
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| Organism | Homo sapiens |
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| Length | 589 residues |
|---|
| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
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| Max clinical phase | — |
|---|
Disease associations (109)
Diseases linked to this target (Open Targets).
- X-linked chondrodysplasia punctata 1 · score 0.82
- chondrodysplasia punctata, brachytelephalangic, autosomal · score 0.53
- Coffin-Siris syndrome · score 0.27
- genetic disorder · score 0.18
- connective tissue disease · score 0.17
- Barrett's esophagus · score 0.06
- esophageal adenocarcinoma · score 0.04
- neoplasm · score 0.02
- chondrodysplasia punctata · score 0.02
- melanoma · score 0.02
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-P51690-F1 | alphafold | PREDICTED | 92.46 | — |
Amino-acid sequence (589 residues)
MLHLHHSCLC FRSWLPAMLA VLLSLAPSAS SDISASRPNI LLLMADDLGI GDIGCYGNNT MRTPNIDRLA EDGVKLTQHI SAASLCTPSR AAFLTGRYPV RSGMVSSIGY RVLQWTGASG GLPTNETTFA KILKEKGYAT GLIGKWHLGL NCESASDHCH HPLHHGFDHF YGMPFSLMGD CARWELSEKR VNLEQKLNFL FQVLALVALT LVAGKLTHLI PVSWMPVIWS ALSAVLLLAS SYFVGALIVH ADCFLMRNHT ITEQPMCFQR TTPLILQEVA SFLKRNKHGP FLLFVSFLHV HIPLITMENF LGKSLHGLYG DNVEEMDWMV GRILDTLDVE GLSNSTLIYF TSDHGGSLEN QLGNTQYGGW NGIYKGGKGM GGWEGGIRVP GIFRWPGVLP AGRVIGEPTS LMDVFPTVVR LAGGEVPQDR VIDGQDLLPL LLGTAQHSDH EFLMHYCERF LHAARWHQRD RGTMWKVHFV TPVFQPEGAG ACYGRKVCPC FGEKVVHHDP PLLFDLSRDP SETHILTPAS EPVFYQVMER VQQAVWEHQR TLSPVPLQLD RLGNIWRPWL QPCCGPFPLC WCLREDDPQ
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