About Potassium voltage-gated channel subfamily KQT member 1
Potassium voltage-gated channel subfamily KQT member 1 (KCNQ1) is a protein
from Homo sapiens identified by UniProt accession
P51787, 676 residues long.
MolForge cross-references it against 0 known binders and
669 disease associations.
Target properties
| Protein name | Potassium voltage-gated channel subfamily KQT member 1 |
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| UniProt accession | P51787 |
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| Gene | KCNQ1 |
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| Organism | Homo sapiens |
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| Length | 676 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Approved drugs hitting this target (2)
DrugCentral-linked approved drugs that act on this protein.
Disease associations (669)
Diseases linked to this target (Open Targets).
- Romano-Ward syndrome · score 0.84
- long QT syndrome 1 · score 0.84
- Jervell and Lange-Nielsen syndrome 1 · score 0.81
- familial long QT syndrome · score 0.73
- atrial fibrillation, familial, 3 · score 0.72
- Jervell and Lange-Nielsen syndrome · score 0.71
- Familial short QT syndrome · score 0.70
- short QT syndrome type 2 · score 0.68
- Prolonged QT interval · score 0.67
- type 2 diabetes mellitus · score 0.61
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-P51787-F1 | alphafold | PREDICTED | 67.74 | — |
Amino-acid sequence (676 residues)
MAAASSPPRA ERKRWGWGRL PGARRGSAGL AKKCPFSLEL AEGGPAGGAL YAPIAPGAPG PAPPASPAAP AAPPVASDLG PRPPVSLDPR VSIYSTRRPV LARTHVQGRV YNFLERPTGW KCFVYHFAVF LIVLVCLIFS VLSTIEQYAA LATGTLFWME IVLVVFFGTE YVVRLWSAGC RSKYVGLWGR LRFARKPISI IDLIVVVASM VVLCVGSKGQ VFATSAIRGI RFLQILRMLH VDRQGGTWRL LGSVVFIHRQ ELITTLYIGF LGLIFSSYFV YLAEKDAVNE SGRVEFGSYA DALWWGVVTV TTIGYGDKVP QTWVGKTIAS CFSVFAISFF ALPAGILGSG FALKVQQKQR QKHFNRQIPA AASLIQTAWR CYAAENPDSS TWKIYIRKAP RSHTLLSPSP KPKKSVVVKK KKFKLDKDNG VTPGEKMLTV PHITCDPPEE RRLDHFSVDG YDSSVRKSPT LLEVSMPHFM RTNSFAEDLD LEGETLLTPI THISQLREHH RATIKVIRRM QYFVAKKKFQ QARKPYDVRD VIEQYSQGHL NLMVRIKELQ RRLDQSIGKP SLFISVSEKS KDRGSNTIGA RLNRVEDKVT QLDQRLALIT DMLHQLLSLH GGSTPGSGGP PREGGAHITQ PCGSGGSVDP ELFLPSNTLP TYEQLTVPRR GPDEGS
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