About H(+)/Cl(-) exchange transporter 3
H(+)/Cl(-) exchange transporter 3 (CLCN3) is a protein
from Homo sapiens identified by UniProt accession
P51790, 818 residues long.
MolForge cross-references it against 0 known binders and
178 disease associations.
Target properties
| Protein name | H(+)/Cl(-) exchange transporter 3 |
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| UniProt accession | P51790 |
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| Gene | CLCN3 |
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| Organism | Homo sapiens |
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| Length | 818 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Disease associations (178)
Diseases linked to this target (Open Targets).
- neurodevelopmental disorder with hypotonia and brain abnormalities · score 0.76
- neurodevelopmental disorder with seizures and brain abnormalities · score 0.63
- Neurodevelopmental delay · score 0.51
- complex neurodevelopmental disorder · score 0.37
- genetic disorder · score 0.34
- schizophrenia · score 0.28
- Neurodevelopmental disorder · score 0.27
- Parkinson disease · score 0.21
- autism spectrum disorder · score 0.18
- glioblastoma multiforme · score 0.18
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-P51790-F1 | alphafold | PREDICTED | 80.03 | — |
Amino-acid sequence (818 residues)
MESEQLFHRG YYRNSYNSIT SASSDEELLD GAGVIMDFQT SEDDNLLDGD TAVGTHYTMT NGGSINSSTH LLDLLDEPIP GVGTYDDFHT IDWVREKCKD RERHRRINSK KKESAWEMTK SLYDAWSGWL VVTLTGLASG ALAGLIDIAA DWMTDLKEGI CLSALWYNHE QCCWGSNETT FEERDKCPQW KTWAELIIGQ AEGPGSYIMN YIMYIFWALS FAFLAVSLVK VFAPYACGSG IPEIKTILSG FIIRGYLGKW TLMIKTITLV LAVASGLSLG KEGPLVHVAC CCGNIFSYLF PKYSTNEAKK REVLSAASAA GVSVAFGAPI GGVLFSLEEV SYYFPLKTLW RSFFAALVAA FVLRSINPFG NSRLVLFYVE YHTPWYLFEL FPFILLGVFG GLWGAFFIRA NIAWCRRRKS TKFGKYPVLE VIIVAAITAV IAFPNPYTRL NTSELIKELF TDCGPLESSS LCDYRNDMNA SKIVDDIPDR PAGIGVYSAI WQLCLALIFK IIMTVFTFGI KVPSGLFIPS MAIGAIAGRI VGIAVEQLAY YHHDWFIFKE WCEVGADCIT PGLYAMVGAA ACLGGVTRMT VSLVVIVFEL TGGLEYIVPL MAAVMTSKWV GDAFGREGIY EAHIRLNGYP FLDAKEEFTH TTLAADVMRP RRNDPPLAVL TQDNMTVDDI ENMINETSYN GFPVIMSKES QRLVGFALRR DLTIAIESAR KKQEGIVGSS RVCFAQHTPS LPAESPRPLK LRSILDMSPF TVTDHTPMEI VVDIFRKLGL RQCLVTHNGR LLGIITKKDI LRHMAQTANQ DPASIMFN
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