About H(+)/Cl(-) exchange transporter 7
H(+)/Cl(-) exchange transporter 7 (CLCN7) is a protein
from Homo sapiens identified by UniProt accession
P51798, 805 residues long.
MolForge cross-references it against 0 known binders and
235 disease associations.
Target properties
| Protein name | H(+)/Cl(-) exchange transporter 7 |
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| UniProt accession | P51798 |
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| Gene | CLCN7 |
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| Organism | Homo sapiens |
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| Length | 805 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Disease associations (235)
Diseases linked to this target (Open Targets).
- autosomal recessive osteopetrosis 4 · score 0.83
- Autosomal recessive malignant osteopetrosis · score 0.79
- autosomal dominant osteopetrosis 2 · score 0.77
- Albers-Schönberg osteopetrosis · score 0.77
- hypopigmentation, organomegaly, and delayed myelination and development · score 0.66
- genetic disorder · score 0.45
- Intermediate osteopetrosis · score 0.39
- Increased bone mineral density · score 0.32
- Abnormality of the skeletal system · score 0.27
- monocyte count · score 0.22
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-P51798-F1 | alphafold | PREDICTED | 80.97 | — |
Amino-acid sequence (805 residues)
MANVSKKVSW SGRDRDDEEA APLLRRTARP GGGTPLLNGA GPGAARQSPR SALFRVGHMS SVELDDELLD PDMDPPHPFP KEIPHNEKLL SLKYESLDYD NSENQLFLEE ERRINHTAFR TVEIKRWVIC ALIGILTGLV ACFIDIVVEN LAGLKYRVIK GNIDKFTEKG GLSFSLLLWA TLNAAFVLVG SVIVAFIEPV AAGSGIPQIK CFLNGVKIPH VVRLKTLVIK VSGVILSVVG GLAVGKEGPM IHSGSVIAAG ISQGRSTSLK RDFKIFEYFR RDTEKRDFVS AGAAAGVSAA FGAPVGGVLF SLEEGASFWN QFLTWRIFFA SMISTFTLNF VLSIYHGNMW DLSSPGLINF GRFDSEKMAY TIHEIPVFIA MGVVGGVLGA VFNALNYWLT MFRIRYIHRP CLQVIEAVLV AAVTATVAFV LIYSSRDCQP LQGGSMSYPL QLFCADGEYN SMAAAFFNTP EKSVVSLFHD PPGSYNPLTL GLFTLVYFFL ACWTYGLTVS AGVFIPSLLI GAAWGRLFGI SLSYLTGAAI WADPGKYALM GAAAQLGGIV RMTLSLTVIM MEATSNVTYG FPIMLVLMTA KIVGDVFIEG LYDMHIQLQS VPFLHWEAPV TSHSLTAREV MSTPVTCLRR REKVGVIVDV LSDTASNHNG FPVVEHADDT QPARLQGLIL RSQLIVLLKH KVFVERSNLG LVQRRLRLKD FRDAYPRFPP IQSIHVSQDE RECTMDLSEF MNPSPYTVPQ EASLPRVFKL FRALGLRHLV VVDNRNQVVG LVTRKDLARY RLGKRGLEEL SLAQT
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