About Chloride channel protein ClC-Ka
Chloride channel protein ClC-Ka (CLCNKA) is a protein
from Homo sapiens identified by UniProt accession
P51800, 687 residues long.
MolForge cross-references it against 0 known binders and
245 disease associations.
Target properties
| Protein name | Chloride channel protein ClC-Ka |
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| UniProt accession | P51800 |
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| Gene | CLCNKA |
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| Organism | Homo sapiens |
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| Length | 687 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Approved drugs hitting this target (1)
DrugCentral-linked approved drugs that act on this protein.
Disease associations (245)
Diseases linked to this target (Open Targets).
- Bartter syndrome · score 0.47
- neurodegenerative disease · score 0.41
- deafness · score 0.40
- Bartter syndrome type 4 · score 0.38
- sensorineural hearing loss · score 0.34
- Sensorineural hearing impairment · score 0.34
- hearing loss, autosomal recessive · score 0.26
- electrocardiography · score 0.23
- left ventricular ejection fraction measurement · score 0.22
- hypertrophic cardiomyopathy · score 0.21
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-P51800-F1 | alphafold | PREDICTED | 87.16 | — |
Amino-acid sequence (687 residues)
MEELVGLREG FSGDPVTLQE LWGPCPHIRR AIQGGLEWLK QKVFRLGEDW YFLMTLGVLM ALVSYAMNFA IGCVVRAHQW LYREIGDSHL LRYLSWTVYP VALVSFSSGF SQSITPSSGG SGIPELKTML AGVILEDYLD IKNFGAKVVG LSCTLATGST LFLGKVGPFV HLSVMIAAYL GRVRTTTIGE PENKSKQNEM LVAAAAVGVA TVFAAPFSGV LFSIEVMSSH FSVRDYWRGF FAATCGAFIF RLLAVFNSEQ ETITSLYKTS FRVDVPFDLP EIFFFVALGG ICGVLSCAYL FCQRTFLSFI KTNRYSSKLL ATSKPVYSAL ATLLLASITY PPGVGHFLAS RLSMKQHLDS LFDNHSWALM TQNSSPPWPE ELDPQHLWWE WYHPRFTIFG TLAFFLVMKF WMLILATTIP MPAGYFMPIF ILGAAIGRLL GEALAVAFPE GIVTGGVTNP IMPGGYALAG AAAFSGAVTH TISTALLAFE LTGQIVHALP VLMAVLAANA IAQSCQPSFY DGTIIVKKLP YLPRILGRNI GSHHVRVEHF MNHSITTLAK DTPLEEVVKV VTSTDVTEYP LVESTESQIL VGIVQRAQLV QALQAEPPSR APGHQQCLQD ILARGCPTEP VTLTLFSETT LHQAQNLFKL LNLQSLFVTS RGRAVGCVSW VEMKKAISNL TNPPAPK
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