About Chloride channel protein ClC-Kb
Chloride channel protein ClC-Kb (CLCNKB) is a protein
from Homo sapiens identified by UniProt accession
P51801, 687 residues long.
MolForge cross-references it against 0 known binders and
260 disease associations.
Target properties
| Protein name | Chloride channel protein ClC-Kb |
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| UniProt accession | P51801 |
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| Gene | CLCNKB |
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| Organism | Homo sapiens |
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| Length | 687 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Approved drugs hitting this target (1)
DrugCentral-linked approved drugs that act on this protein.
Disease associations (260)
Diseases linked to this target (Open Targets).
- Bartter disease type 3 · score 0.79
- Bartter syndrome · score 0.66
- Gitelman syndrome · score 0.38
- Bartter syndrome type 4 · score 0.38
- hematocrit · score 0.38
- familial focal epilepsy with variable foci · score 0.34
- erythrocyte count · score 0.32
- hemoglobin measurement · score 0.31
- Hematuria · score 0.30
- Proteinuria · score 0.30
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-P51801-F1 | alphafold | PREDICTED | 87.22 | — |
Amino-acid sequence (687 residues)
MEEFVGLREG SSGNPVTLQE LWGPCPRIRR GIRGGLEWLK QKLFRLGEDW YFLMTLGVLM ALVSCAMDLA VESVVRAHQW LYREIGDSHL LRYLSWTVYP VALVSFSSGF SQSITPSSGG SGIPEVKTML AGVVLEDYLD IKNFGAKVVG LSCTLACGST LFLGKVGPFV HLSVMMAAYL GRVRTTTIGE PENKSKQNEM LVAAAAVGVA TVFAAPFSGV LFSIEVMSSH FSVWDYWRGF FAATCGAFMF RLLAVFNSEQ ETITSLYKTS FRVDVPFDLP EIFFFVALGG LCGILGSAYL FCQRIFFGFI RNNRFSSKLL ATSKPVYSAL ATLVLASITY PPSAGRFLAS RLSMKQHLDS LFDNHSWALM TQNSSPPWPE ELDPQHLWWE WYHPRFTIFG TLAFFLVMKF WMLILATTIP MPAGYFMPIF VYGAAIGRLF GETLSFIFPE GIVAGGITNP IMPGGYALAG AAAFSGAVTH TISTALLAFE VTGQIVHALP VLMAVLAANA IAQSCQPSFY DGTVIVKKLP YLPRILGRNI GSHRVRVEHF MNHSITTLAK DMPLEEVVKV VTSTDVAKYP LVESTESQIL VGIVRRAQLV QALKAEPPSW APGHQQCLQD ILAAGCPTEP VTLKLSPETS LHEAHNLFEL LNLHSLFVTS RGRAVGCVSW VEMKKAISNL TNPPAPK
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