About Plexin-A3
Plexin-A3 (PLXNA3) is a protein
from Homo sapiens identified by UniProt accession
P51805, 1871 residues long.
MolForge cross-references it against 0 known binders and
275 disease associations.
Target properties
| Protein name | Plexin-A3 |
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| UniProt accession | P51805 |
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| Gene | PLXNA3 |
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| Organism | Homo sapiens |
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| Length | 1871 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
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| Max clinical phase | — |
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Disease associations (275)
Diseases linked to this target (Open Targets).
- hypogonadotropic hypogonadism · score 0.41
- Hypogonadotropic hypogonadism · score 0.37
- Short stature · score 0.32
- autism · score 0.15
- Neurodevelopmental disorder · score 0.12
- disorder of sexual differentiation · score 0.11
- microtia · score 0.11
- Genetic 46,XY disorder of sex development · score 0.11
- lung adenocarcinoma · score 0.10
- head and neck squamous cell carcinoma · score 0.09
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-P51805-F1 | alphafold | PREDICTED | 84.46 | — |
Amino-acid sequence (1871 residues)
MPSVCLLLLL FLAVGGALGN RPFRAFVVTD TTLTHLAVHR VTGEVFVGAV NRVFKLAPNL TELRAHVTGP VEDNARCYPP PSMRVCAHRL APVDNINKLL LIDYAARRLV ACGSIWQGIC QFLRLDDLFK LGEPHHRKEH YLSGAQEPDS MAGVIVEQGQ GPSKLFVGTA VDGKSEYFPT LSSRKLISDE DSADMFSLVY QDEFVSSQIK IPSDTLSLYP AFDIYYIYGF VSASFVYFLT LQLDTQQTLL DTAGEKFFTS KIVRMCAGDS EFYSYVEFPI GCSWRGVEYR LVQSAHLAKP GLLLAQALGV PADEDVLFTI FSQGQKNRAS PPRQTILCLF TLSNINAHIR RRIQSCYRGE GTLALPWLLN KELPCINTPM QINGNFCGLV LNQPLGGLHV IEGLPLLADS TDGMASVAAY TYRQHSVVFI GTRSGSLKKV RVDGFQDAHL YETVPVVDGS PILRDLLFSP DHRHIYLLSE KQVSQLPVET CEQYQSCAAC LGSGDPHCGW CVLRHRCCRE GACLGASAPH GFAEELSKCV QVRVRPNNVS VTSPGVQLTV TLHNVPDLSA GVSCAFEAAA ENEAVLLPSG ELLCPSPSLQ ELRALTRGHG ATRTVRLQLL SKETGVRFAG ADFVFYNCSV LQSCMSCVGS PYPCHWCKYR HTCTSRPHEC SFQEGRVHSP EGCPEILPSG DLLIPVGVMQ PLTLRAKNLP QPQSGQKNYE CVVRVQGRQQ RVPAVRFNSS SVQCQNASYS YEGDEHGDTE LDFSVVWDGD FPIDKPPSFR ALLYKCWAQR PSCGLCLKAD PRFNCGWCIS EHRCQLRTHC PAPKTNWMHL SQKGTRCSHP RITQIHPLVG PKEGGTRVTI VGENLGLLSR EVGLRVAGVR CNSIPAEYIS AERIVCEMEE SLVPSPPPGP VELCVGDCSA DFRTQSEQVY SFVTPTFDQV SPSRGPASGG TRLTISGSSL DAGSRVTVTV RDSECQFVRR DAKAIVCISP LSTLGPSQAP ITLAIDRANI SSPGLIYTYT QDPTVTRLEP TWSIINGSTA ITVSGTHLLT VQEPRVRAKY RGIETTNTCQ VINDTAMLCK APGIFLGRPQ PRAQGEHPDE FGFLLDHVQT ARSLNRSSFT YYPDPSFEPL GPSGVLDVKP GSHVVLKGKN LIPAAAGSSR LNYTVLIGGQ PCSLTVSDTQ LLCDSPSQTG RQPVMVLVGG LEFWLGTLHI SAERALTLPA MMGLAAGGGL LLLAITAVLV AYKRKTQDAD RTLKRLQLQM DNLESRVALE CKEAFAELQT DINELTNHMD EVQIPFLDYR TYAVRVLFPG IEAHPVLKEL DTPPNVEKAL RLFGQLLHSR AFVLTFIHTL EAQSSFSMRD RGTVASLTMV ALQSRLDYAT GLLKQLLADL IEKNLESKNH PKLLLRRTES VAEKMLTNWF TFLLHKFLKE CAGEPLFLLY CAIKQQMEKG PIDAITGEAR YSLSEDKLIR QQIDYKTLTL HCVCPENEGS AQVPVKVLNC DSITQAKDKL LDTVYKGIPY SQRPKAEDMD LEWRQGRMTR IILQDEDVTT KIECDWKRLN SLAHYQVTDG SLVALVPKQV SAYNMANSFT FTRSLSRYES LLRTASSPDS LRSRAPMITP DQETGTKLWH LVKNHDHADH REGDRGSKMV SEIYLTRLLA TKGTLQKFVD DLFETVFSTA HRGSALPLAI KYMFDFLDEQ ADQRQISDPD VRHTWKSNCL PLRFWVNVIK NPQFVFDIHK NSITDACLSV VAQTFMDSCS TSEHRLGKDS PSNKLLYAKD IPNYKSWVER YYRDIAKMAS ISDQDMDAYL VEQSRLHASD FSVLSALNEL YFYVTKYRQE ILTALDRDAS CRKHKLRQKL EQIISLVSSD S
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