G-protein coupled receptor 143 (GPR143)

About G-protein coupled receptor 143

G-protein coupled receptor 143 (GPR143) is a protein from Homo sapiens identified by UniProt accession P51810, 404 residues long. MolForge cross-references it against 0 known binders and 175 disease associations.

Target properties

Protein name	G-protein coupled receptor 143
UniProt accession	P51810
Gene	GPR143
Organism	Homo sapiens
Length	404 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (175)

Diseases linked to this target (Open Targets).

X-linked recessive ocular albinism · score 0.84
nystagmus 6, congenital, X-linked · score 0.69
genetic disorder · score 0.47
Nystagmus · score 0.44
ocular albinism · score 0.44
inherited retinal dystrophy · score 0.37
albinism · score 0.33
Reduced eye contact · score 0.27
glioblastoma multiforme · score 0.24
lung adenocarcinoma · score 0.19

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-P51810-F1	alphafold	PREDICTED	73.54	—

Amino-acid sequence (404 residues)

MASPRLGTFC CPTRDAATQL VLSFQPRAFH ALCLGSGGLR LALGLLQLLP GRRPAGPGSP ATSPPASVRI LRAAAACDLL GCLGMVIRST VWLGFPNFVD SVSDMNHTEI WPAAFCVGSA MWIQLLYSAC FWWLFCYAVD AYLVIRRSAG LSTILLYHIM AWGLATLLCV EGAAMLYYPS VSRCERGLDH AIPHYVTMYL PLLLVLVANP ILFQKTVTAV ASLLKGRQGI YTENERRMGA VIKIRFFKIM LVLIICWLSN IINESLLFYL EMQTDINGGS LKPVRTAAKT TWFIMGILNP AQGFLLSLAF YGWTGCSLGF QSPRKEIQWE SLTTSAAEGA HPSPLMPHEN PASGKVSQVG GQTSDEALSM LSEGSDASTI EIHTASESCN KNEGDPALPT HGDL

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards