About Endoplasmic reticulum membrane adapter protein XK
Endoplasmic reticulum membrane adapter protein XK (XK) is a protein
from Homo sapiens identified by UniProt accession
P51811, 444 residues long.
MolForge cross-references it against 0 known binders and
457 disease associations.
Target properties
| Protein name | Endoplasmic reticulum membrane adapter protein XK |
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| UniProt accession | P51811 |
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| Gene | XK |
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| Organism | Homo sapiens |
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| Length | 444 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Disease associations (457)
Diseases linked to this target (Open Targets).
- McLeod neuroacanthocytosis syndrome · score 0.80
- genetic disorder · score 0.40
- clear cell renal carcinoma · score 0.28
- isolated asymptomatic elevation of creatine phosphokinase · score 0.27
- glioblastoma multiforme · score 0.26
- Elevated circulating creatine kinase concentration · score 0.26
- breast adenocarcinoma · score 0.17
- head and neck squamous cell carcinoma · score 0.16
- low grade glioma · score 0.14
- endometrial cancer · score 0.12
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-P51811-F1 | alphafold | PREDICTED | 81.62 | — |
Amino-acid sequence (444 residues)
MKFPASVLAS VFLFVAETTA ALSLSSTYRS GGDRMWQALT LLFSLLPCAL VQLTLLFVHR DLSRDRPLVL LLHLLQLGPL FRCFEVFCIY FQSGNNEEPY VSITKKRQMP KNGLSEEIEK EVGQAEGKLI THRSAFSRAS VIQAFLGSAP QLTLQLYISV MQQDVTVGRS LLMTISLLSI VYGALRCNIL AIKIKYDEYE VKVKPLAYVC IFLWRSFEIA TRVVVLVLFT SVLKTWVVVI ILINFFSFFL YPWILFWCSG SPFPENIEKA LSRVGTTIVL CFLTLLYTGI NMFCWSAVQL KIDSPDLISK SHNWYQLLVY YMIRFIENAI LLLLWYLFKT DIYMYVCAPL LVLQLLIGYC TAILFMLVFY QFFHPCKKLF SSSVSEGFQR WLRCFCWACR QQKPCEPIGK EDLQSSRDRD ETPSSSKTSP EPGQFLNAED LCSA
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