About Ribosomal protein S6 kinase alpha-3
Ribosomal protein S6 kinase alpha-3 (RPS6KA3) is a protein
from Homo sapiens identified by UniProt accession
P51812, 740 residues long.
MolForge cross-references it against 0 known binders and
446 disease associations.
Target properties
| Protein name | Ribosomal protein S6 kinase alpha-3 |
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| UniProt accession | P51812 |
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| Gene | RPS6KA3 |
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| Organism | Homo sapiens |
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| Length | 740 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Approved drugs hitting this target (11)
DrugCentral-linked approved drugs that act on this protein.
Disease associations (446)
Diseases linked to this target (Open Targets).
- Coffin-Lowry syndrome · score 0.83
- intellectual disability, X-linked 19 · score 0.75
- X-linked non-syndromic intellectual disability · score 0.66
- genetic disorder · score 0.54
- Intellectual disability · score 0.54
- hepatocellular carcinoma · score 0.53
- Global developmental delay · score 0.37
- Motor delay · score 0.37
- symptomatic form of Coffin-Lowry syndrome in female carriers · score 0.37
- Macrocephaly · score 0.34
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-P51812-F1 | alphafold | PREDICTED | 76.16 | — |
Amino-acid sequence (740 residues)
MPLAQLADPW QKMAVESPSD SAENGQQIMD EPMGEEEINP QTEEVSIKEI AITHHVKEGH EKADPSQFEL LKVLGQGSFG KVFLVKKISG SDARQLYAMK VLKKATLKVR DRVRTKMERD ILVEVNHPFI VKLHYAFQTE GKLYLILDFL RGGDLFTRLS KEVMFTEEDV KFYLAELALA LDHLHSLGII YRDLKPENIL LDEEGHIKLT DFGLSKESID HEKKAYSFCG TVEYMAPEVV NRRGHTQSAD WWSFGVLMFE MLTGTLPFQG KDRKETMTMI LKAKLGMPQF LSPEAQSLLR MLFKRNPANR LGAGPDGVEE IKRHSFFSTI DWNKLYRREI HPPFKPATGR PEDTFYFDPE FTAKTPKDSP GIPPSANAHQ LFRGFSFVAI TSDDESQAMQ TVGVHSIVQQ LHRNSIQFTD GYEVKEDIGV GSYSVCKRCI HKATNMEFAV KIIDKSKRDP TEEIEILLRY GQHPNIITLK DVYDDGKYVY VVTELMKGGE LLDKILRQKF FSEREASAVL FTITKTVEYL HAQGVVHRDL KPSNILYVDE SGNPESIRIC DFGFAKQLRA ENGLLMTPCY TANFVAPEVL KRQGYDAACD IWSLGVLLYT MLTGYTPFAN GPDDTPEEIL ARIGSGKFSL SGGYWNSVSD TAKDLVSKML HVDPHQRLTA ALVLRHPWIV HWDQLPQYQL NRQDAPHLVK GAMAATYSAL NRNQSPVLEP VGRSTLAQRR GIKKITSTAL
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