About cAMP-dependent protein kinase catalytic subunit PRKX
cAMP-dependent protein kinase catalytic subunit PRKX (PRKX) is a protein
from Homo sapiens identified by UniProt accession
P51817, 358 residues long.
MolForge cross-references it against 0 known binders and
56 disease associations.
Target properties
| Protein name | cAMP-dependent protein kinase catalytic subunit PRKX |
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| UniProt accession | P51817 |
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| Gene | PRKX |
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| Organism | Homo sapiens |
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| Length | 358 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Approved drugs hitting this target (1)
DrugCentral-linked approved drugs that act on this protein.
Disease associations (56)
Diseases linked to this target (Open Targets).
- neurodegenerative disease · score 0.49
- Hashimoto's thyroiditis · score 0.33
- Mayer-Rokitansky-Kuster-Hauser syndrome · score 0.07
- lymphocyte count · score 0.04
- blood urea nitrogen measurement · score 0.03
- thyroid stimulating hormone measurement · score 0.03
- leukocyte count · score 0.03
- Mayer-Rokitansky-Küster-Hauser syndrome · score 0.03
- acute myocardial infarction · score 0.02
- medulloblastoma · score 0.02
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-P51817-F1 | alphafold | PREDICTED | 88.60 | — |
Amino-acid sequence (358 residues)
MEAPGLAQAA AAESDSRKVA EETPDGAPAL CPSPEALSPE PPVYSLQDFD TLATVGTGTF GRVHLVKEKT AKHFFALKVM SIPDVIRLKQ EQHVHNEKSV LKEVSHPFLI RLFWTWHDER FLYMLMEYVP GGELFSYLRN RGRFSSTTGL FYSAEIICAI EYLHSKEIVY RDLKPENILL DRDGHIKLTD FGFAKKLVDR TWTLCGTPEY LAPEVIQSKG HGRAVDWWAL GILIFEMLSG FPPFFDDNPF GIYQKILAGK IDFPRHLDFH VKDLIKKLLV VDRTRRLGNM KNGANDVKHH RWFRSVDWEA VPQRKLKPPI VPKIAGDGDT SNFETYPEND WDTAAPVPQK DLEIFKNF
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