About Nuclear receptor subfamily 0 group B member 1
Nuclear receptor subfamily 0 group B member 1 (NR0B1) is a protein
from Homo sapiens identified by UniProt accession
P51843, 470 residues long.
MolForge cross-references it against 0 known binders and
445 disease associations.
Target properties
| Protein name | Nuclear receptor subfamily 0 group B member 1 |
|---|
| UniProt accession | P51843 |
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| Gene | NR0B1 |
|---|
| Organism | Homo sapiens |
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| Length | 470 residues |
|---|
| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
|---|
| Pocket score | — |
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| Max clinical phase | — |
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Disease associations (445)
Diseases linked to this target (Open Targets).
- X-linked adrenal hypoplasia congenita · score 0.82
- Cytomegalic congenital adrenal hypoplasia · score 0.77
- 46,XY complete gonadal dysgenesis · score 0.65
- neurodegenerative disease · score 0.48
- alternating hemiplegia of childhood · score 0.46
- genetic disorder · score 0.19
- 46,XY partial gonadal dysgenesis · score 0.09
- hepatocellular carcinoma · score 0.09
- azoospermia · score 0.08
- 46,XX testicular disorder of sex development · score 0.08
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-P51843-F1 | alphafold | PREDICTED | 59.49 | — |
Amino-acid sequence (470 residues)
MAGENHQWQG SILYNMLMSA KQTRAAPEAP ETRLVDQCWG CSCGDEPGVG REGLLGGRNV ALLYRCCFCG KDHPRQGSIL YSMLTSAKQT YAAPKAPEAT LGPCWGCSCG SDPGVGRAGL PGGRPVALLY RCCFCGEDHP RQGSILYSLL TSSKQTHVAP AAPEARPGGA WWDRSYFAQR PGGKEALPGG RATALLYRCC FCGEDHPQQG STLYCVPTST NQAQAAPEER PRAPWWDTSS GALRPVALKS PQVVCEAASA GLLKTLRFVK YLPCFQVLPL DQQLVLVRNC WASLLMLELA QDRLQFETVE VSEPSMLQKI LTTRRRETGG NEPLPVPTLQ HHLAPPAEAR KVPSASQVQA IKCFLSKCWS LNISTKEYAY LKGTVLFNPD VPGLQCVKYI QGLQWGTQQI LSEHTRMTHQ GPHDRFIELN STLFLLRFIN ANVIAELFFR PIIGTVSMDD MMLEMLCTKI
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