About Hepatoma-derived growth factor
Hepatoma-derived growth factor (HDGF) is a protein
from Homo sapiens identified by UniProt accession
P51858, 240 residues long.
MolForge cross-references it against 0 known binders and
166 disease associations.
Target properties
| Protein name | Hepatoma-derived growth factor |
|---|
| UniProt accession | P51858 |
|---|
| Gene | HDGF |
|---|
| Organism | Homo sapiens |
|---|
| Length | 240 residues |
|---|
| Molecular weight | — |
|---|
| EC numbers | — |
|---|
| Target class | UNCLASSIFIED |
|---|
| Subcellular location | — |
|---|
| Keywords | — |
|---|
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
|---|
Disease associations (166)
Diseases linked to this target (Open Targets).
- neurodegenerative disease · score 0.29
- Red cell distribution width · score 0.23
- total blood protein measurement · score 0.20
- blood protein measurement · score 0.18
- bilirubin measurement · score 0.16
- platelet count · score 0.16
- sex hormone-binding globulin measurement · score 0.16
- high density lipoprotein cholesterol measurement · score 0.16
- body height · score 0.12
- hepatocellular carcinoma · score 0.11
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-P51858-F1 | alphafold | PREDICTED | 66.94 | — |
Amino-acid sequence (240 residues)
MSRSNRQKEY KCGDLVFAKM KGYPHWPARI DEMPEAAVKS TANKYQVFFF GTHETAFLGP KDLFPYEESK EKFGKPNKRK GFSEGLWEIE NNPTVKASGY QSSQKKSCVE EPEPEPEAAE GDGDKKGNAE GSSDEEGKLV IDEPAKEKNE KGALKRRAGD LLEDSPKRPK EAENPEGEEK EAATLEVERP LPMEVEKNST PSEPGSGRGP PQEEEEEEDE EEEATKEDAE APGIRDHESL
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