About Caspase-5
Caspase-5 (CASP5) is a protein
from Homo sapiens identified by UniProt accession
P51878, 434 residues long.
MolForge cross-references it against 0 known binders and
151 disease associations.
Target properties
| Protein name | Caspase-5 |
|---|
| UniProt accession | P51878 |
|---|
| Gene | CASP5 |
|---|
| Organism | Homo sapiens |
|---|
| Length | 434 residues |
|---|
| Molecular weight | — |
|---|
| EC numbers | — |
|---|
| Target class | UNCLASSIFIED |
|---|
| Subcellular location | — |
|---|
| Keywords | — |
|---|
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
|---|
Disease associations (151)
Diseases linked to this target (Open Targets).
- schizophrenia · score 0.16
- interleukin 18 measurement · score 0.12
- cirrhosis of liver · score 0.09
- non-alcoholic steatohepatitis · score 0.07
- chronic hepatitis C virus infection · score 0.07
- psoriasis · score 0.06
- hyperinsulinism due to INSR deficiency · score 0.05
- MODY · score 0.05
- esophageal adenocarcinoma · score 0.05
- hyperinsulinism due to glucokinase deficiency · score 0.05
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-P51878-F1 | alphafold | PREDICTED | 68.98 | — |
Amino-acid sequence (434 residues)
MAEDSGKKKR RKNFEAMFKG ILQSGLDNFV INHMLKNNVA GQTSIQTLVP NTDQKSTSVK KDNHKKKTVK MLEYLGKDVL HGVFNYLAKH DVLTLKEEEK KKYYDTKIED KALILVDSLR KNRVAHQMFT QTLLNMDQKI TSVKPLLQIE AGPPESAEST NILKLCPREE FLRLCKKNHD EIYPIKKRED RRRLALIICN TKFDHLPARN GAHYDIVGMK RLLQGLGYTV VDEKNLTARD MESVLRAFAA RPEHKSSDST FLVLMSHGIL EGICGTAHKK KKPDVLLYDT IFQIFNNRNC LSLKDKPKVI IVQACRGEKH GELWVRDSPA SLALISSQSS ENLEADSVCK IHEEKDFIAF CSSTPHNVSW RDRTRGSIFI TELITCFQKY SCCCHLMEIF RKVQKSFEVP QAKAQMPTIE RATLTRDFYL FPGN
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