Prolargin (PRELP)

About Prolargin

Prolargin (PRELP) is a protein from Homo sapiens identified by UniProt accession P51888, 382 residues long. MolForge cross-references it against 0 known binders and 141 disease associations.

Target properties

Protein name	Prolargin
UniProt accession	P51888
Gene	PRELP
Organism	Homo sapiens
Length	382 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (141)

Diseases linked to this target (Open Targets).

blood protein measurement · score 0.27
cutaneous melanoma · score 0.26
lung adenocarcinoma · score 0.25
body fat percentage · score 0.21
type 2 diabetes mellitus · score 0.21
sex hormone-binding globulin measurement · score 0.20
triglyceride measurement · score 0.20
hip circumference · score 0.19
BMI-adjusted waist-hip ratio · score 0.19
BMI-adjusted hip circumference · score 0.19

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-P51888-F1	alphafold	PREDICTED	86.15	—

Amino-acid sequence (382 residues)

MRSPLCWLLP LLILASVAQG QPTRRPRPGT GPGRRPRPRP RPTPSFPQPD EPAEPTDLPP PLPPGPPSIF PDCPRECYCP PDFPSALYCD SRNLRKVPVI PPRIHYLYLQ NNFITELPVE SFQNATGLRW INLDNNRIRK IDQRVLEKLP GLVFLYMEKN QLEEVPSALP RNLEQLRLSQ NHISRIPPGV FSKLENLLLL DLQHNRLSDG VFKPDTFHGL KNLMQLNLAH NILRKMPPRV PTAIHQLYLD SNKIETIPNG YFKSFPNLAF IRLNYNKLTD RGLPKNSFNI SNLLVLHLSH NRISSVPAIN NRLEHLYLNN NSIEKINGTQ ICPNDLVAFH DFSSDLENVP HLRYLRLDGN YLKPPIPLDL MMCFRLLQSV VI

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards