About Cyclin-H
Cyclin-H (CCNH) is a protein
from Homo sapiens identified by UniProt accession
P51946, 323 residues long.
MolForge cross-references it against 0 known binders and
86 disease associations.
Target properties
| Protein name | Cyclin-H |
|---|
| UniProt accession | P51946 |
|---|
| Gene | CCNH |
|---|
| Organism | Homo sapiens |
|---|
| Length | 323 residues |
|---|
| Molecular weight | — |
|---|
| EC numbers | — |
|---|
| Target class | UNCLASSIFIED |
|---|
| Subcellular location | — |
|---|
| Keywords | — |
|---|
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
|---|
Disease associations (86)
Diseases linked to this target (Open Targets).
- HIV infection · score 0.59
- neurodegenerative disease · score 0.45
- Capillary malformation - arteriovenous malformation · score 0.34
- capillary malformation-arteriovenous malformation syndrome · score 0.34
- endometrial cancer · score 0.28
- breast adenocarcinoma · score 0.27
- type 2 diabetes mellitus · score 0.26
- ovarian cancer · score 0.25
- lung adenocarcinoma · score 0.19
- mean corpuscular hemoglobin · score 0.19
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-P51946-F1 | alphafold | PREDICTED | 86.36 | — |
Amino-acid sequence (323 residues)
MYHNSSQKRH WTFSSEEQLA RLRADANRKF RCKAVANGKV LPNDPVFLEP HEEMTLCKYY EKRLLEFCSV FKPAMPRSVV GTACMYFKRF YLNNSVMEYH PRIIMLTCAF LACKVDEFNV SSPQFVGNLR ESPLGQEKAL EQILEYELLL IQQLNFHLIV HNPYRPFEGF LIDLKTRYPI LENPEILRKT ADDFLNRIAL TDAYLLYTPS QIALTAILSS ASRAGITMES YLSESLMLKE NRTCLSQLLD IMKSMRNLVK KYEPPRSEEV AVLKQKLERC HSAELALNVI TKKRKGYEDD DYVSKKSKHE EEEWTDDDLV ESL
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