CDK-activating kinase assembly factor MAT1 (MNAT1)

About CDK-activating kinase assembly factor MAT1

CDK-activating kinase assembly factor MAT1 (MNAT1) is a protein from Homo sapiens identified by UniProt accession P51948, 309 residues long. MolForge cross-references it against 0 known binders and 37 disease associations.

Target properties

Protein name	CDK-activating kinase assembly factor MAT1
UniProt accession	P51948
Gene	MNAT1
Organism	Homo sapiens
Length	309 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (37)

Diseases linked to this target (Open Targets).

HIV infection · score 0.59
neurodegenerative disease · score 0.34
protein measurement · score 0.27
breast adenocarcinoma · score 0.27
ovarian cancer · score 0.25
head and neck squamous cell carcinoma · score 0.24
response to vaccine · score 0.23
cytokine measurement · score 0.23
lung adenocarcinoma · score 0.18
gastric adenocarcinoma · score 0.17

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-P51948-F1	alphafold	PREDICTED	85.34	—

Amino-acid sequence (309 residues)

MDDQGCPRCK TTKYRNPSLK LMVNVCGHTL CESCVDLLFV RGAGNCPECG TPLRKSNFRV QLFEDPTVDK EVEIRKKVLK IYNKREEDFP SLREYNDFLE EVEEIVFNLT NNVDLDNTKK KMEIYQKENK DVIQKNKLKL TREQEELEEA LEVERQENEQ RRLFIQKEEQ LQQILKRKNK QAFLDELESS DLPVALLLAQ HKDRSTQLEM QLEKPKPVKP VTFSTGIKMG QHISLAPIHK LEEALYEYQP LQIETYGPHV PELEMLGRLG YLNHVRAASP QDLAGGYTSS LACHRALQDA FSGLFWQPS

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards