About Serine/threonine-protein kinase Nek4
Serine/threonine-protein kinase Nek4 (NEK4) is a protein
from Homo sapiens identified by UniProt accession
P51957, 841 residues long.
MolForge cross-references it against 0 known binders and
124 disease associations.
Target properties
| Protein name | Serine/threonine-protein kinase Nek4 |
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| UniProt accession | P51957 |
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| Gene | NEK4 |
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| Organism | Homo sapiens |
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| Length | 841 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Approved drugs hitting this target (2)
DrugCentral-linked approved drugs that act on this protein.
Disease associations (124)
Diseases linked to this target (Open Targets).
- neurodegenerative disease · score 0.36
- ciliopathy · score 0.26
- mean corpuscular hemoglobin concentration · score 0.20
- bipolar disorder · score 0.15
- schizophrenia · score 0.15
- mean corpuscular hemoglobin · score 0.14
- self reported educational attainment · score 0.13
- blood protein measurement · score 0.12
- BMI-adjusted waist-hip ratio · score 0.12
- BMI-adjusted waist circumference · score 0.11
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-P51957-F1 | alphafold | PREDICTED | 57.84 | — |
Amino-acid sequence (841 residues)
MPLAAYCYLR VVGKGSYGEV TLVKHRRDGK QYVIKKLNLR NASSRERRAA EQEAQLLSQL KHPNIVTYKE SWEGGDGLLY IVMGFCEGGD LYRKLKEQKG QLLPENQVVE WFVQIAMALQ YLHEKHILHR DLKTQNVFLT RTNIIKVGDL GIARVLENHC DMASTLIGTP YYMSPELFSN KPYNYKSDVW ALGCCVYEMA TLKHAFNAKD MNSLVYRIIE GKLPPMPRDY SPELAELIRT MLSKRPEERP SVRSILRQPY IKRQISFFLE ATKIKTSKNN IKNGDSQSKP FATVVSGEAE SNHEVIHPQP LSSEGSQTYI MGEGKCLSQE KPRASGLLKS PASLKAHTCK QDLSNTTELA TISSVNIDIL PAKGRDSVSD GFVQENQPRY LDASNELGGI CSISQVEEEM LQDNTKSSAQ PENLIPMWSS DIVTGEKNEP VKPLQPLIKE QKPKDQSLAL SPKLECSGTI LAHSNLRLLG SSDSPASASR VAGITGVCHH AQDQVAGECI IEKQGRIHPD LQPHNSGSEP SLSRQRRQKR REQTEHRGEK RQVRRDLFAF QESPPRFLPS HPIVGKVDVT STQKEAENQR RVVTGSVSSS RSSEMSSSKD RPLSARERRR LKQSQEEMSS SGPSVRKASL SVAGPGKPQE EDQPLPARRL SSDCSVTQER KQIHCLSEDE LSSSTSSTDK SDGDYGEGKG QTNEINALVQ LMTQTLKLDS KESCEDVPVA NPVSEFKLHR KYRDTLILHG KVAEEAEEIH FKELPSAIMP GSEKIRRLVE VLRTDVIRGL GVQLLEQVYD LLEEEDEFDR EVRLREHMGE KYTTYSVKAR QLKFFEENMN F
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